7jzq
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jzq OCA], [https://pdbe.org/7jzq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jzq RCSB], [https://www.ebi.ac.uk/pdbsum/7jzq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jzq ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jzq OCA], [https://pdbe.org/7jzq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jzq RCSB], [https://www.ebi.ac.uk/pdbsum/7jzq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jzq ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Disease == | ||
| - | [https://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
CFTR Associated Ligand (CAL) PDZ domain bound to peptidomimetic LyCALPMB
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