7s2r
From Proteopedia
(Difference between revisions)
| Line 8: | Line 8: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s2r OCA], [https://pdbe.org/7s2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s2r RCSB], [https://www.ebi.ac.uk/pdbsum/7s2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s2r ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s2r OCA], [https://pdbe.org/7s2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s2r RCSB], [https://www.ebi.ac.uk/pdbsum/7s2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s2r ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Disease == | ||
| - | [https://www.uniprot.org/uniprot/IL2RG_HUMAN IL2RG_HUMAN] Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID) [MIM:[https://omim.org/entry/300400 300400]; also known as agammaglobulinemia Swiss type. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.<ref>PMID:8401490</ref> <ref>PMID:8299698</ref> <ref>PMID:8088810</ref> <ref>PMID:8027558</ref> <ref>PMID:7937790</ref> <ref>PMID:7668284</ref> <ref>PMID:7557965</ref> <ref>PMID:7860773</ref> <ref>PMID:8900089</ref> <ref>PMID:9150740</ref> Defects in IL2RG are the cause of X-linked combined immunodeficiency (XCID) [MIM:[https://omim.org/entry/312863 312863]. XCID is a less severe form of X-linked immunodeficiency with a less severe degree of deficiency in cellular and humoral immunity than that seen in XSCID.<ref>PMID:7883965</ref> <ref>PMID:9399950</ref> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/IL2RG_HUMAN IL2RG_HUMAN] Common subunit for the receptors for a variety of interleukins. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Current revision
nanobody bound to IL-2Rg
| |||||||||||
