Retroviral integrase 3D structures
From Proteopedia
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**[[3kkr]], [[3kks]] – IN catalytic core domain – BIV | **[[3kkr]], [[3kks]] – IN catalytic core domain – BIV | ||
| - | * | + | *HIV-1 integrase; Domains – N-terminal zinc-binding 728-773; catalytic core 50-212; C-terminal 219-273; C-terminal DBD 947-997; CCD 1197-1359; intasome 1-288 + DNA |
**[[6u8q]], [[6vdk]] – intasome – Cryo EM <br /> | **[[6u8q]], [[6vdk]] – intasome – Cryo EM <br /> | ||
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**[[4ahr]], [[4ahs]], [[4aht]], [[4ahu]] - IN CCD domain (mutant) + inhibitor <br /> | **[[4ahr]], [[4ahs]], [[4aht]], [[4ahu]] - IN CCD domain (mutant) + inhibitor <br /> | ||
**[[1hyv]], [[1hyz]], [[4cer]], [[4chp]], [[4chy]], [[4o0j]], [[5krt]], [[5krs]], [[5kgx]], [[5kgw]], [[6ex9]], [[6um8]], [[6vkh]], [[6vlh]], [[6vlm]], [[6vqs]], [[6vx2]], [[6w0u]], [[6w42]], [[6wc8]], [[6we7]], [[7d83]], [[7ke0]], [[7l1p]], [[7l23]], [[7l2y]], [[7lqp]], [[7rq0]], [[7sia]], [[7t9h]], [[7t9o]], [[7u2u]], [[7uoq]], [[7wce]], [[8bv2]], [[8cbr]] – IN catalytic core domain + inhibitor <br /> | **[[1hyv]], [[1hyz]], [[4cer]], [[4chp]], [[4chy]], [[4o0j]], [[5krt]], [[5krs]], [[5kgx]], [[5kgw]], [[6ex9]], [[6um8]], [[6vkh]], [[6vlh]], [[6vlm]], [[6vqs]], [[6vx2]], [[6w0u]], [[6w42]], [[6wc8]], [[6we7]], [[7d83]], [[7ke0]], [[7l1p]], [[7l23]], [[7l2y]], [[7lqp]], [[7rq0]], [[7sia]], [[7t9h]], [[7t9o]], [[7u2u]], [[7uoq]], [[7wce]], [[8bv2]], [[8cbr]] – IN catalytic core domain + inhibitor <br /> | ||
| - | **[[1qs4]], [[3nf6]], [[3nf7]], [[3nf8]], [[3nf9]], [[3nfa]], [[3zsv]], [[3zsx]], [[3zt2]], [[4ceb]], [[4ces]], [[4cf9]], [[4chq]], [[4cj4]], [[4cjt]], [[4cju]], [[4e1m]], [[4e1n]], [[4jlh]], [[4lh4]], [[4nyf]], [[4o55]], [[4o5b]], [[4ojr]], [[4ovl]], [[4tsx]], [[5hrs]], [[5hrr]], [[5hrp]], [[5hrn]], [[ | + | **[[1qs4]], [[3nf6]], [[3nf7]], [[3nf8]], [[3nf9]], [[3nfa]], [[3zsv]], [[3zsx]], [[3zt2]], [[4ceb]], [[4ces]], [[4cf9]], [[4chq]], [[4cj4]], [[4cjt]], [[4cju]], [[4e1m]], [[4e1n]], [[4jlh]], [[4lh4]], [[4nyf]], [[4o55]], [[4o5b]], [[4ojr]], [[4ovl]], [[4tsx]], [[5hrs]], [[5hrr]], [[5hrp]], [[5hrn]], [[8v9c]], [[6eb1]], [[6eb2]], [[6lmi]], [[6lmq]], [[6ncj]], [[6nuj]], [[6vka]], [[7ue1]], [[8ct7]], [[8d3s]] - IN core domain (mutant) + inhibitor<br /> |
**[[8a1p]], [[8cbs]], [[8cbu]], [[8cta]] – IN catalytic core+ C-terminal domains + inhibitor <br /> | **[[8a1p]], [[8cbs]], [[8cbu]], [[8cta]] – IN catalytic core+ C-terminal domains + inhibitor <br /> | ||
**[[8a1q]] – IN catalytic core+ C-terminal domains + drug <br /> | **[[8a1q]] – IN catalytic core+ C-terminal domains + drug <br /> | ||
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**[[8fn7]], [[8fnd]], [[8fng]], [[8fnh]], [[8fnj]], [[8fnl]], [[8fnm]], [[8fnn]], [[8fno]], [[8fnp]], [[8fnq]] – IN intasome (mutant) + drug <br /> | **[[8fn7]], [[8fnd]], [[8fng]], [[8fnh]], [[8fnj]], [[8fnl]], [[8fnm]], [[8fnn]], [[8fno]], [[8fnp]], [[8fnq]] – IN intasome (mutant) + drug <br /> | ||
| - | * | + | *HIV-2 integrase |
**[[6qbt]] – IN catalytic core domain <br /> | **[[6qbt]] – IN catalytic core domain <br /> | ||
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**[[5m0r]], [[7zpp]], [[7u32]] – intasome – Cryo EM<br /> | **[[5m0r]], [[7zpp]], [[7u32]] – intasome – Cryo EM<br /> | ||
| - | * | + | *SIV integrase |
**[[1c6v]] – IN catalytic domain (mutant) + DNA binding domain - SIV <br /> | **[[1c6v]] – IN catalytic domain (mutant) + DNA binding domain - SIV <br /> | ||
Current revision
3D Structures of Retroviral Integrase
Updated on 19-March-2025
