1nox

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[[Image:1nox.gif|left|200px]]
 
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==NADH OXIDASE FROM THERMUS THERMOPHILUS==
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The line below this paragraph, containing "STRUCTURE_1nox", creates the "Structure Box" on the page.
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<StructureSection load='1nox' size='340' side='right'caption='[[1nox]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1nox]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NOX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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{{STRUCTURE_1nox| PDB=1nox | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nox OCA], [https://pdbe.org/1nox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nox RCSB], [https://www.ebi.ac.uk/pdbsum/1nox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nox ProSAT]</span></td></tr>
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</table>
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'''NADH OXIDASE FROM THERMUS THERMOPHILUS'''
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== Function ==
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[https://www.uniprot.org/uniprot/NOX_THET8 NOX_THET8] Can oxidize either NADH or NADPH with a preference for NADH. Can catalyze electron transfer from NADH to various electron acceptors which include, in addition to molecular oxygen, cytochrome c, 2,6 dichlorphenolindophenol, methylene blue, ferricyanide or P-nitroblue tetrazolium.
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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The crystal structures of the flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) containing isoforms of NADH oxidase from Thermus thermophilus have been determined by isomorphous and molecular replacement and refined to 2.3 A and 1.6 A resolution with R-values of 18.5% and 18.6% respectively. The structure of the homodimeric enzyme consists of a central 4-stranded antiparallel beta-sheet covered by helices, a more flexible domain formed by two helices, and a C-terminal excursion connecting the subunits. The active sites are located in a deep cleft between the subunits. The binding site of the flavin cofactor lacks the common nucleotide binding fold and is different from the FMN binding site found in flavodoxins.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/no/1nox_consurf.spt"</scriptWhenChecked>
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1NOX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NOX OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Crystal structure of NADH oxidase from Thermus thermophilus., Hecht HJ, Erdmann H, Park HJ, Sprinzl M, Schmid RD, Nat Struct Biol. 1995 Dec;2(12):1109-14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8846223 8846223]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nox ConSurf].
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[[Category: NADH dehydrogenase]]
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<div style="clear:both"></div>
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[[Category: Single protein]]
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__TOC__
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[[Category: Thermus thermophilus]]
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</StructureSection>
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[[Category: Erdmann, H.]]
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[[Category: Large Structures]]
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[[Category: Hecht, H J.]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Park, H J.]]
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[[Category: Erdmann H]]
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[[Category: Schmid, R D.]]
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[[Category: Hecht HJ]]
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[[Category: Sprinzl, M.]]
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[[Category: Park HJ]]
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[[Category: Flavoenzyme]]
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[[Category: Schmid RD]]
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[[Category: Flavoprotein fmn]]
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[[Category: Sprinzl M]]
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[[Category: Oxidoreductase]]
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[[Category: Thermophile]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:47:57 2008''
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Current revision

NADH OXIDASE FROM THERMUS THERMOPHILUS

PDB ID 1nox

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