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1npo

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[[Image:1npo.gif|left|200px]]
 
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==BOVINE NEUROPHYSIN II COMPLEX WITH OXYTOCIN==
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The line below this paragraph, containing "STRUCTURE_1npo", creates the "Structure Box" on the page.
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<StructureSection load='1npo' size='340' side='right'caption='[[1npo]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1npo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NPO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1npo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1npo OCA], [https://pdbe.org/1npo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1npo RCSB], [https://www.ebi.ac.uk/pdbsum/1npo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1npo ProSAT]</span></td></tr>
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{{STRUCTURE_1npo| PDB=1npo | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NEU2_BOVIN NEU2_BOVIN] Neurophysin 2 specifically binds vasopressin. Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/np/1npo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1npo ConSurf].
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<div style="clear:both"></div>
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'''BOVINE NEUROPHYSIN II COMPLEX WITH OXYTOCIN'''
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==See Also==
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*[[Neurophysin|Neurophysin]]
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__TOC__
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==Overview==
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</StructureSection>
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The first crystal structure of the pituitary hormone oxytocin complexed with its carrier protein neurophysin has been determined and refined to 3.0 A resolution. The hormone-binding site is located at the end of a 3(10)-helix and involves residues from both domains of each monomer. Hormone residues Tyr 2, which is buried deep in the binding pocket, and Cys 1 have been confirmed as the key residues involved in neurophysin-hormone recognition. We have compared the bound oxytocin observed in the neurophysin-oxytocin complex, the X-ray structures of unbound oxytocin analogues and the NMR-derived structure for bound oxytocin. We find that while our structure is in agreement with the previous crystallographic findings, it differs from the NMR result with regard to how Tyr 2 of the hormone is recognized by neurophysin.
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==About this Structure==
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1NPO is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPO OCA].
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==Reference==
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Crystal structure of the neurophysin-oxytocin complex., Rose JP, Wu CK, Hsiao CD, Breslow E, Wang BC, Nat Struct Biol. 1996 Feb;3(2):163-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8564543 8564543]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Rose, J P.]]
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[[Category: Rose JP]]
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[[Category: Wang, B C.]]
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[[Category: Wang B-C]]
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[[Category: Hypothalamus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:49:40 2008''
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Current revision

BOVINE NEUROPHYSIN II COMPLEX WITH OXYTOCIN

PDB ID 1npo

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