8j97

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'''Unreleased structure'''
 
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The entry 8j97 is ON HOLD until Paper Publication
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==Structure of Muscarinic receptor (M2R) in complex with beta-arrestin1 (Local refine, cross-linked)==
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<StructureSection load='8j97' size='340' side='right'caption='[[8j97]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8j97]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J97 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J97 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j97 OCA], [https://pdbe.org/8j97 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j97 RCSB], [https://www.ebi.ac.uk/pdbsum/8j97 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j97 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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beta-arrestins (betaarrs) are multifunctional proteins involved in signaling and regulation of seven transmembrane receptors (7TMRs), and their interaction is driven primarily by agonist-induced receptor activation and phosphorylation. Here, we present seven cryo-electron microscopy structures of betaarrs either in the basal state, activated by the muscarinic receptor subtype 2 (M2R) through its third intracellular loop, or activated by the betaarr-biased decoy D6 receptor (D6R). Combined with biochemical, cellular, and biophysical experiments, these structural snapshots allow the visualization of atypical engagement of betaarrs with 7TMRs and also reveal a structural transition in the carboxyl terminus of betaarr2 from a beta strand to an alpha helix upon activation by D6R. Our study provides previously unanticipated molecular insights into the structural and functional diversity encoded in 7TMR-betaarr complexes with direct implications for exploring novel therapeutic avenues.
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Authors: Maharana, J., Sano, F.K., Shihoya, S., Banerjee, R., Nureki, O., Shukla, A.K.
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Molecular insights into atypical modes of beta-arrestin interaction with seven transmembrane receptors.,Maharana J, Sano FK, Sarma P, Yadav MK, Duan L, Stepniewski TM, Chaturvedi M, Ranjan A, Singh V, Saha S, Mahajan G, Chami M, Shihoya W, Selent J, Chung KY, Banerjee R, Nureki O, Shukla AK Science. 2024 Jan 5;383(6678):101-108. doi: 10.1126/science.adj3347. Epub 2024 , Jan 4. PMID:38175886<ref>PMID:38175886</ref>
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Description: Structure of Muscarinic receptor (M2R) in complex with beta-arrestin1 (Local refine, cross-linked)
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Nureki, O]]
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<div class="pdbe-citations 8j97" style="background-color:#fffaf0;"></div>
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[[Category: Shukla, A.K]]
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== References ==
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[[Category: Maharana, J]]
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<references/>
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[[Category: Banerjee, R]]
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__TOC__
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[[Category: Shihoya, S]]
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</StructureSection>
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[[Category: Sano, F.K]]
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[[Category: Bos taurus]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Banerjee R]]
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[[Category: Maharana J]]
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[[Category: Nureki O]]
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[[Category: Sano FK]]
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[[Category: Shihoya W]]
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[[Category: Shukla AK]]

Current revision

Structure of Muscarinic receptor (M2R) in complex with beta-arrestin1 (Local refine, cross-linked)

PDB ID 8j97

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