1op1

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(New page: 200px<br /> <applet load="1op1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1op1" /> '''Solution NMR structure of domain 1 of recep...)
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[[Image:1op1.gif|left|200px]]<br />
 
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<applet load="1op1" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1op1" />
 
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'''Solution NMR structure of domain 1 of receptor associated protein'''<br />
 
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==Overview==
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==Solution NMR structure of domain 1 of receptor associated protein==
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The 39 kDa receptor associated protein (RAP) is a modular protein, consisting of multiple domains. There has been no x-ray crystal structure, of RAP available and the full-length protein does not behave well in a NMR, tube. To elucidate the 3D structure of the RAP, we undertook structure, determination of individual domains of the RAP. As the first step, here we, report the nearly complete assignments of the (1)H, (13)C and (15)N, chemical shift signals of domain 1 of the RAP.
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<StructureSection load='1op1' size='340' side='right'caption='[[1op1]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1op1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OP1 FirstGlance]. <br>
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1OP1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OP1 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1op1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1op1 OCA], [https://pdbe.org/1op1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1op1 RCSB], [https://www.ebi.ac.uk/pdbsum/1op1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1op1 ProSAT]</span></td></tr>
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==Reference==
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</table>
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1H, 13C and 15N resonance assignments of domain 1 of receptor associated protein., Wu Y, Migliorini M, Yu P, Strickland DK, Wang YX, J Biomol NMR. 2003 Jun;26(2):187-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12766414 12766414]
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== Disease ==
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[https://www.uniprot.org/uniprot/AMRP_HUMAN AMRP_HUMAN] Note=In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.
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== Function ==
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[https://www.uniprot.org/uniprot/AMRP_HUMAN AMRP_HUMAN] Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/op/1op1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1op1 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Migliorini, M.]]
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[[Category: Migliorini M]]
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[[Category: Strickland, D.K.]]
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[[Category: Strickland DK]]
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[[Category: Wang, Y-X.]]
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[[Category: Wang Y-X]]
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[[Category: Wu, Y.]]
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[[Category: Wu Y]]
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[[Category: Yu, P.]]
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[[Category: Yu P]]
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[[Category: helical bundle]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 18:35:01 2007''
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Current revision

Solution NMR structure of domain 1 of receptor associated protein

PDB ID 1op1

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