8qjx
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qjx OCA], [https://pdbe.org/8qjx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qjx RCSB], [https://www.ebi.ac.uk/pdbsum/8qjx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qjx ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qjx OCA], [https://pdbe.org/8qjx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qjx RCSB], [https://www.ebi.ac.uk/pdbsum/8qjx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qjx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Disease == | ||
| - | [https://www.uniprot.org/uniprot/DSG2_HUMAN DSG2_HUMAN] Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10) [MIM:[https://omim.org/entry/610193 610193]; also known as arrhythmogenic right ventricular cardiomyopathy 10 (ARVC10). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.<ref>PMID:16773573</ref> <ref>PMID:20031617</ref> <ref>PMID:19863551</ref> <ref>PMID:21062920</ref> Genetic variations in DSG2 are the cause of susceptibility to cardiomyopathy dilated type 1BB (CMD1BB) [MIM:[https://omim.org/entry/612877 612877]. A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:18678517</ref> | ||
== Function == | == Function == | ||
| - | [https://www.uniprot.org/uniprot/ | + | [https://www.uniprot.org/uniprot/SPIKE_ADE1P SPIKE_ADE1P] Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor CD46 to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface. |
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The main limitation of oncolytic vectors is neutralization by blood components, which prevents intratumoral administration to patients. Enadenotucirev, a chimeric HAdV-11p/HAdV-3 adenovirus identified by bio-selection, is a low seroprevalence vector active against a broad range of human carcinoma cell lines. At this stage, there's still some uncertainty about tropism and primary receptor utilization by HAdV-11. However, this information is very important, as it has a direct influence on the effectiveness of HAdV-11-based vectors. The aim of this work is to determine which of the two receptors, DSG2 and CD46, is involved in the attachment of the virus to the host, and what role they play in the early stages of infection. | ||
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| + | Toward the understanding of DSG2 and CD46 interaction with HAdV-11 fiber, a super-complex analysis.,Effantin G, Hograindleur M-A, Fenel D, Fender P, Vassal-Stermann E J Virol. 2023 Nov 30;97(11):e0091023. doi: 10.1128/jvi.00910-23. Epub 2023 Nov 3. PMID:37921471<ref>PMID:37921471</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 8qjx" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
Human Adenovirus type 11 fiber knob in complex with two copies of its cell receptor, Desmoglein-2
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