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1jia

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(New page: 200px<br /> <applet load="1jia" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jia, resolution 2.13&Aring;" /> '''STRUCTURE OF A BASI...)
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[[Image:1jia.gif|left|200px]]<br />
 
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<applet load="1jia" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1jia, resolution 2.13&Aring;" />
 
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'''STRUCTURE OF A BASIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS AT 2.13A RESOLUTION'''<br />
 
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==Overview==
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==STRUCTURE OF A BASIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS AT 2.13A RESOLUTION==
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The basic phospholipase A2 isolated from the venom of Agkistrodon halys, Pallas (Agkistrodon blomhoffii Brevicaudus) is a hemolytic toxin and one, of the few PLA2's capable of hydrolyzing the phospholipids of E. coli, membranes in the presence of a bactericidal/permeability-increasing, protein (BPI) of neutrophils. The crystal structure has been determined, and refined at 2.13 A to an R factor of 16.5% (F &gt; 3sigma) with excellent, stereochemistry. A superposition of the two molecules in the asymmetric, unit gives an r. m.s. deviation of 0.326 A for all Calpha atoms. The, refined structure allowed a detailed comparison with other PLA2 species of, known structures. The overall architecture is similar to those of other, PLA2's with a few significant differences. One of which is in the ... [[http://ispc.weizmann.ac.il/pmbin/getpm?9761847 (full description)]]
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<StructureSection load='1jia' size='340' side='right'caption='[[1jia]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1jia]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JIA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jia OCA], [https://pdbe.org/1jia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jia RCSB], [https://www.ebi.ac.uk/pdbsum/1jia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jia ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PA2BB_GLOHA PA2BB_GLOHA] Snake venom phospholipase A2 (PLA2) that shows potent hemolytic activity, and exhibits medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 90 nM). It is one of the few phospholipases A2 capable of hydrolyzing the phospholipids of E.coli membranes in the presence of a bactericidal/permeability-increasing protein (BPI) of neutrophils. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18062812</ref> <ref>PMID:10728829</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ji/1jia_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jia ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1JIA is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]] with CA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JIA OCA]].
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
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== References ==
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==Reference==
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<references/>
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Structure of a basic phospholipase A2 from Agkistrodon halys Pallas at 2.13 A resolution., Zhao K, Song S, Lin Z, Zhou Y, Acta Crystallogr D Biol Crystallogr. 1998 Jul 1;54(Pt 4):510-21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9761847 9761847]
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__TOC__
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</StructureSection>
[[Category: Gloydius halys]]
[[Category: Gloydius halys]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Lin, Z.]]
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[[Category: Lin Z]]
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[[Category: Zhao, K.]]
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[[Category: Zhao K]]
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[[Category: CA]]
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[[Category: agkistrodon halys pallas crystal structure]]
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[[Category: phospholipase a2]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 18:23:36 2007''
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STRUCTURE OF A BASIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS AT 2.13A RESOLUTION

PDB ID 1jia

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