1o0k

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[[Image:1o0k.gif|left|200px]]
 
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==Structure of the First Parallel DNA Quadruplex-drug Complex==
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The line below this paragraph, containing "STRUCTURE_1o0k", creates the "Structure Box" on the page.
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<StructureSection load='1o0k' size='340' side='right'caption='[[1o0k]], [[Resolution|resolution]] 1.17&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1o0k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O0K FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.17&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DM1:DAUNOMYCIN'>DM1</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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{{STRUCTURE_1o0k| PDB=1o0k | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o0k OCA], [https://pdbe.org/1o0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o0k RCSB], [https://www.ebi.ac.uk/pdbsum/1o0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o0k ProSAT]</span></td></tr>
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</table>
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'''Structure of the First Parallel DNA Quadruplex-drug Complex'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Clark GR]]
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The first crystal structure of a drug (daunomycin) bound to a parallel-stranded intermolecular telomeric G4 quadruplex (d(TGGGGT)4) has been determined to high resolution. A planar assemblage of three daunomycin molecules stacks onto the 5' end of the G4 column, with the daunosamine substituents occupying three of the four quadruplex grooves. The surface area of the terminal G-quartet in this parallel DNA quadruplex, presently occupied by three daunomycins, is sufficiently large that it could easily accommodate other potential telomerase inhibitors such as substituted porphyrins or telomestatin.
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[[Category: Neidle S]]
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[[Category: Pytel PD]]
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==About this Structure==
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[[Category: Squire CJ]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O0K OCA].
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==Reference==
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Structure of the first parallel DNA quadruplex-drug complex., Clark GR, Pytel PD, Squire CJ, Neidle S, J Am Chem Soc. 2003 Apr 9;125(14):4066-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12670225 12670225]
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[[Category: Clark, G R.]]
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[[Category: Neidle, S.]]
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[[Category: Pytel, P D.]]
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[[Category: Squire, C J.]]
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[[Category: G-4 quadruplex drug complex]]
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[[Category: Parallel quadruplex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:12:46 2008''
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Current revision

Structure of the First Parallel DNA Quadruplex-drug Complex

PDB ID 1o0k

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