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8r09
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of the cross-exon pre-B+5'ss+ATPgammaS complex== | |
| - | + | <StructureSection load='8r09' size='340' side='right'caption='[[8r09]], [[Resolution|resolution]] 4.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8r09]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8R09 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8R09 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.3Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8r09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8r09 OCA], [https://pdbe.org/8r09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8r09 RCSB], [https://www.ebi.ac.uk/pdbsum/8r09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8r09 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LSM6_HUMAN LSM6_HUMAN] Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Dybkov O]] | ||
| + | [[Category: Kastner B]] | ||
| + | [[Category: Kumar V]] | ||
| + | [[Category: Ludwig S]] | ||
| + | [[Category: Luehrmann R]] | ||
| + | [[Category: Stark H]] | ||
| + | [[Category: Urlaub H]] | ||
| + | [[Category: Will CL]] | ||
| + | [[Category: Zhang Z]] | ||
| + | [[Category: Zhong J]] | ||
Current revision
Cryo-EM structure of the cross-exon pre-B+5'ss+ATPgammaS complex
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Categories: Homo sapiens | Large Structures | Dybkov O | Kastner B | Kumar V | Ludwig S | Luehrmann R | Stark H | Urlaub H | Will CL | Zhang Z | Zhong J
