8t9z
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structural of M8C10 Fab in complex human metapneumovirus fusion protein== | |
| + | <StructureSection load='8t9z' size='340' side='right'caption='[[8t9z]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8t9z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_metapneumovirus Human metapneumovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8T9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8T9Z FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.995Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8t9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8t9z OCA], [https://pdbe.org/8t9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8t9z RCSB], [https://www.ebi.ac.uk/pdbsum/8t9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8t9z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/G3KCK8_9MONO G3KCK8_9MONO] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Human metapneumovirus (hMPV) is a common pathogen causing lower respiratory tract infections worldwide and can develop severe symptoms in high-risk populations such as infants, the elderly, and immunocompromised patients. There are no approved hMPV vaccines or neutralizing antibodies available for therapeutic or prophylactic use. The trimeric hMPV fusion F protein is the major target of neutralizing antibodies in human sera. Understanding the immune recognition of antibodies to hMPV-F antigen will provide critical insights into developing efficacious hMPV monoclonal antibodies and vaccines. | ||
| - | + | Structural characterization of M8C10, a neutralizing antibody targeting a highly conserved prefusion-specific epitope on the metapneumovirus fusion trimerization interface.,Xiao X, Wen Z, Chen Q, Shipman JM, Kostas J, Reid JC, Warren C, Tang A, Luo B, O'Donnell G, Fridman A, Chen Z, Vora KA, Zhang L, Su H-P, Eddins MJ J Virol. 2023 Dec 21;97(12):e0105223. doi: 10.1128/jvi.01052-23. Epub 2023 Nov , 30. PMID:38032197<ref>PMID:38032197</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 8t9z" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Human metapneumovirus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Eddins MJ]] | ||
| + | [[Category: Kostas J]] | ||
| + | [[Category: Reid JC]] | ||
| + | [[Category: Shipman JM]] | ||
| + | [[Category: Su HP]] | ||
Current revision
Structural of M8C10 Fab in complex human metapneumovirus fusion protein
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