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1p53

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(New page: 200px<br /> <applet load="1p53" size="450" color="white" frame="true" align="right" spinBox="true" caption="1p53, resolution 3.06&Aring;" /> '''The Crystal Structu...)
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[[Image:1p53.gif|left|200px]]<br />
 
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<applet load="1p53" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1p53, resolution 3.06&Aring;" />
 
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'''The Crystal Structure of ICAM-1 D3-D5 fragment'''<br />
 
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==Overview==
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==The Crystal Structure of ICAM-1 D3-D5 fragment==
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We have determined the 3.0 A crystal structure of the three C-terminal, domains 3-5 (D3-D5) of ICAM-1. Combined with the previously known, N-terminal two-domain structure (D1D2), a model of an entire ICAM-1, extracellular fragment has been constructed. This model should represent a, general architecture of other ICAM family members, particularly ICAM-3 and, ICAM-5. The observed intimate dimerization interaction at D4 and a stiff, D4-D5 stem-like architecture provide a good structural explanation for the, existence of preformed ICAM-1 cis dimers on the cell membrane. Together, with another dimerization interface at D1, a band-like one-dimensional, linear cluster of ICAM-1 on an antigen-presenting cell (APC) surface can, be envisioned, which might explain the formation of an immunological, synapse between an activated T cell and APC which is critical for T cell, receptor signaling.
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<StructureSection load='1p53' size='340' side='right'caption='[[1p53]], [[Resolution|resolution]] 3.06&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1p53]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P53 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.06&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p53 OCA], [https://pdbe.org/1p53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p53 RCSB], [https://www.ebi.ac.uk/pdbsum/1p53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p53 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ICAM1_HUMAN ICAM1_HUMAN] ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.<ref>PMID:2538243</ref> <ref>PMID:1968231</ref> <ref>PMID:11173916</ref> <ref>PMID:17875742</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p5/1p53_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p53 ConSurf].
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<div style="clear:both"></div>
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==Disease==
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==See Also==
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Known disease associated with this structure: Malaria, cerebral, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147840 147840]]
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*[[Intercellular adhesion molecule|Intercellular adhesion molecule]]
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== References ==
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==About this Structure==
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<references/>
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1P53 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG and NDG as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1P53 OCA].
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__TOC__
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</StructureSection>
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==Reference==
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Structural basis for dimerization of ICAM-1 on the cell surface., Yang Y, Jun CD, Liu JH, Zhang R, Joachimiak A, Springer TA, Wang JH, Mol Cell. 2004 Apr 23;14(2):269-76. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15099525 15099525]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Jochimiak, A.]]
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[[Category: Jochimiak A]]
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[[Category: Jun, C.D.]]
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[[Category: Jun CD]]
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[[Category: Liu, J.H.]]
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[[Category: Liu JH]]
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[[Category: Springer, T.A.]]
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[[Category: Springer TA]]
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[[Category: Wang, J.H.]]
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[[Category: Wang JH]]
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[[Category: Yang, Y.]]
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[[Category: Yang Y]]
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[[Category: Zhang, R.]]
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[[Category: Zhang R]]
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[[Category: NAG]]
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[[Category: NDG]]
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[[Category: beta-sheet]]
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[[Category: dimer]]
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[[Category: igsf domain]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 18:40:09 2007''
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Current revision

The Crystal Structure of ICAM-1 D3-D5 fragment

PDB ID 1p53

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