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RNA polymerase 3D structures
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**[[7ccg]] - RNAP subunit δ - ''Streptomyces albulus''<br /> | **[[7ccg]] - RNAP subunit δ - ''Streptomyces albulus''<br /> | ||
**[[7ok0]], [[7oqy]] – SaRNAP – ''Sulfolobus acidocaldarius'' – Cryo EM<br /> | **[[7ok0]], [[7oqy]] – SaRNAP – ''Sulfolobus acidocaldarius'' – Cryo EM<br /> | ||
| - | **[[8h02]] – SeRNAP subunit | + | **[[8h02]] – SeRNAP subunit – ''Synechococcus elongatus''<br /> |
| - | **[[8emb]] – RNAP subunit ’ si3 domain – Thermosynechococcus vestitus<br /> | + | **[[8emb]] – RNAP subunit ’ si3 domain – ''Thermosynechococcus vestitus''<br /> |
| - | **[[8dkc]] – RNAP subunits | + | **[[8dkc]] – RNAP subunits α,β,β',ω - ''Porphyromonas gingivalis'' – Cryo EM<br /> |
*Prokaryotic DNA-dependent RNAP complex with DNA/RNA or elongation complex | *Prokaryotic DNA-dependent RNAP complex with DNA/RNA or elongation complex | ||
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**[[4v8s]] – SsRNAP + DNA<br /> | **[[4v8s]] – SsRNAP + DNA<br /> | ||
**[[3q22]], [[3q23]], [[3q24]], [[4ff1]], [[4ff2]], [[4ff3]], [[4ff4]] – RNAP + DNA – Enterobacteria phage N4<br /> | **[[3q22]], [[3q23]], [[3q24]], [[4ff1]], [[4ff2]], [[4ff3]], [[4ff4]] – RNAP + DNA – Enterobacteria phage N4<br /> | ||
| - | **[[2o5i]], [[2o5j]], [[4gzy]], [[4gzz]], [[4xln]], [[4xlr]] – TtRNAP subunits | + | **[[2o5i]], [[2o5j]], [[4gzy]], [[4gzz]], [[4xln]], [[4xlr]] – TtRNAP subunits α,β,β',ω + DNA +RNA<br /> |
**[[6m6c]], [[8hsg]], [[8hsr]] - TtRNAP in elongation complex – Cryo EM<br /> | **[[6m6c]], [[8hsg]], [[8hsr]] - TtRNAP in elongation complex – Cryo EM<br /> | ||
| - | **[[5x22]] - TtRNAP subunits | + | **[[5x22]] - TtRNAP subunits α,β,β',ω + DNA + RNA + CMPCPP<br /> |
| - | **[[5x21]] - TtRNAP subunits | + | **[[5x21]] - TtRNAP subunits α,β,β',ω + DNA + RNA + antibiotic<br /> |
| - | **[[4wqs]], [[4xlp]], [[4xlq]], [[4xls]], [[5tjg]] - TtRNAP subunits | + | **[[4wqs]], [[4xlp]], [[4xlq]], [[4xls]], [[5tjg]] - TtRNAP subunits α,β,β',ω + DNA<br /> |
| - | **[[2ppb]] - TtRNAP subunits | + | **[[2ppb]] - TtRNAP subunits α,β,β',ω + antibiotic + DNA + RNA + substrate analog<br /> |
| - | **[[4yg2]], [[4jk1]], [[4jk2]], [[4jkr]], [[4kmu]] - EcRNAP subunits | + | **[[4yg2]], [[4jk1]], [[4jk2]], [[4jkr]], [[4kmu]] - EcRNAP subunits α,β,β',ω + RNA<br /> |
**[[8aby]], [[8ac0]], [[8acp]], [[8ad1]] - EcRNAP in elongation complex + RNA putL – Cryo EM<br /> | **[[8aby]], [[8ac0]], [[8acp]], [[8ad1]] - EcRNAP in elongation complex + RNA putL – Cryo EM<br /> | ||
**[[6flp]], [[6bjs]], [[6asx]], [[6alh]], [[6alf]], [[6rip]], [[6ri9]], [[7q0j]], [[7q0k]], [[7tyb]], [[7xue]], [[7xug]], [[7yp9]], [[8abz]], [[8ac1]], [[8ac2]], [[8eg7]], [[8eg8]], [[8egb]], [[8eh8]] , [[8eh9]], [[8eha]], [[8ehf]], [[8ehi]], [[8f1i]], [[8f1k]], [[8f3c]], [[8fix]], [[8fiy]], [[8fvr]], [[8fvw]], [[8g00]], [[8g1s]], [[8g2w]], [[8g7e]], [[8pbl]] - EcRNAP in elongation complex – Cryo EM<br /> | **[[6flp]], [[6bjs]], [[6asx]], [[6alh]], [[6alf]], [[6rip]], [[6ri9]], [[7q0j]], [[7q0k]], [[7tyb]], [[7xue]], [[7xug]], [[7yp9]], [[8abz]], [[8ac1]], [[8ac2]], [[8eg7]], [[8eg8]], [[8egb]], [[8eh8]] , [[8eh9]], [[8eha]], [[8ehf]], [[8ehi]], [[8f1i]], [[8f1k]], [[8f3c]], [[8fix]], [[8fiy]], [[8fvr]], [[8fvw]], [[8g00]], [[8g1s]], [[8g2w]], [[8g7e]], [[8pbl]] - EcRNAP in elongation complex – Cryo EM<br /> | ||
**[[7ypa]] - EcRNAP in transcription-termination complex – Cryo EM<br /> | **[[7ypa]] - EcRNAP in transcription-termination complex – Cryo EM<br /> | ||
| - | **[[6rh3]] - EcRNAP subunits | + | **[[6rh3]] - EcRNAP subunits α,β,β',ω + RNA + DNA + GMP + CTP – Cryo EM<br /> |
| - | **[[4kn4]], [[4kn7]] - EcRNAP subunits | + | **[[4kn4]], [[4kn7]] - EcRNAP subunits α,β,β',ω + RNA + antibiotic<br /> |
**[[6vvv]] – MsRNAP in translation initiation complex <br /> | **[[6vvv]] – MsRNAP in translation initiation complex <br /> | ||
**[[7p5x]] – MsRNAP in translation initiation complex + PafBC – Cryo EM<br /> | **[[7p5x]] – MsRNAP in translation initiation complex + PafBC – Cryo EM<br /> | ||
| - | **[[6vvx]], [[6vvy]], [[6vvs]], [[6vvt]], [[6vvz]] – MsRNAP subunits | + | **[[6vvx]], [[6vvy]], [[6vvs]], [[6vvt]], [[6vvz]] – MsRNAP subunits α,β,β',ω + DNA + antibiotic<br /> |
| - | **[[7l7b]] – RNAP subunits | + | **[[7l7b]] – RNAP subunits α,β,β',ω + sigma factor SIGA + antibiotic – ''Clostridia difficalis'' – Cryo EM<br /> |
| - | **[[8gzg]], [[8gzh]] – RNAP elongation | + | **[[8gzg]], [[8gzh]] – RNAP elongation complex + sigma factor SIGA – ''Synechocystic'' – Cryo EM<br /> |
*''Prokaryotic DNA-dependent RNAP complex with protein'' | *''Prokaryotic DNA-dependent RNAP complex with protein'' | ||
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**[[3mmp]] - EcRNAP subunit β + EF-TU<br /> | **[[3mmp]] - EcRNAP subunit β + EF-TU<br /> | ||
**[[7egs]] - EcRNAP subunit β + DNA helicase II 654-720<br /> | **[[7egs]] - EcRNAP subunit β + DNA helicase II 654-720<br /> | ||
| - | **[[4ljz]], [[4lk1]], [[4mey]], [[4xsx]], [[4xsy]], [[4xsz]], [[4zh2]], [[4zh3]] , [[4zh4 | + | **[[4ljz]], [[4lk1]], [[4mey]], [[4xsx]], [[4xsy]], [[4xsz]], [[4zh2]], [[4zh3]] , [[4zh4]], [[5nwt]], [[5uag]], [[5uah]], [[5uaj]], [[5ual]], [[5uaq]], [[5ui8]] - EcRNAP subunits α,β,β’,ω + σ factor <br /> |
**[[6c9y]] - EcRNAP subunits α,β,β’,ω + σ factor – Cryo EM<br /> | **[[6c9y]] - EcRNAP subunits α,β,β’,ω + σ factor – Cryo EM<br /> | ||
**[[4mex]] - EcRNAP subunits α,β,β’,ω + σ factor + salinamide<br /> | **[[4mex]] - EcRNAP subunits α,β,β’,ω + σ factor + salinamide<br /> | ||
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**[[5uhf]], [[5uhe]] - MtuRNAP subunits α,β,β’,ω + σ factor + DNA + RNA + inhibitor<br /> | **[[5uhf]], [[5uhe]] - MtuRNAP subunits α,β,β’,ω + σ factor + DNA + RNA + inhibitor<br /> | ||
**[[1l9z]] - TaRNAP subunits α,β,β’,ω + σ factor + DNA<br /> | **[[1l9z]] - TaRNAP subunits α,β,β’,ω + σ factor + DNA<br /> | ||
| - | **[[8i23]], [[8i24]] - RNAP subunits α,β,β’,ω + σ factor SIGI1 + DNA – Clostridium thermocellum - Cryo EM<br /> | + | **[[8i23]], [[8i24]] - RNAP subunits α,β,β’,ω + σ factor SIGI1 + DNA – ''Clostridium thermocellum'' - Cryo EM<br /> |
*''Prokaryotic DNA-dependent RNAP complex with protein + DNA/RNA'' | *''Prokaryotic DNA-dependent RNAP complex with protein + DNA/RNA'' | ||
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**[[7d7c]] - EcRNAP subunits α,β,β’,ω + GP55 + DNA - Cryo EM<br /> | **[[7d7c]] - EcRNAP subunits α,β,β’,ω + GP55 + DNA - Cryo EM<br /> | ||
**[[7d7d]] - EcRNAP subunits α,β,β’,ω + DNAP clamp + GP55 + DNA - Cryo EM<br /> | **[[7d7d]] - EcRNAP subunits α,β,β’,ω + DNAP clamp + GP55 + DNA - Cryo EM<br /> | ||
| - | **[[6n4c]], [[6oul]], [[ | + | **[[6n4c]], [[6oul]], [[7khc]], [[7khb]], [[7n4e]] - EcRNAP subunits α,β,β’,ω + RPOD + DNA – Cryo EM<br /> |
**[[7szj]], [[7szk]] - EcRNAP subunits α,β,β’,ω + RPOD + DNA + drug – Cryo EM<br /> | **[[7szj]], [[7szk]] - EcRNAP subunits α,β,β’,ω + RPOD + DNA + drug – Cryo EM<br /> | ||
**[[6ldi]] - EcRNAP subunits α,β,β’,ω + RPOD + CUER + DNA + RNA – Cryo EM<br /> | **[[6ldi]] - EcRNAP subunits α,β,β’,ω + RPOD + CUER + DNA + RNA – Cryo EM<br /> | ||
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**[[7kin]] - MtuRNAP subunits α,β,β’,ω + σ factor + DNA + RBPA – Cryo EM<br /> | **[[7kin]] - MtuRNAP subunits α,β,β’,ω + σ factor + DNA + RBPA – Cryo EM<br /> | ||
**[[7kif]], [[7kim]] - MtuRNAP subunits α,β,β’,ω + σ factor + DNA + RBPA + CARD + Whib7 – Cryo EM<br /> | **[[7kif]], [[7kim]] - MtuRNAP subunits α,β,β’,ω + σ factor + DNA + RBPA + CARD + Whib7 – Cryo EM<br /> | ||
| - | **[[6wmp]] - FtRNAP subunits α,β,β’,ω + RNA + DNA – Francisella tularensis - Cryo EM<br /> | + | **[[6wmp]] - FtRNAP subunits α,β,β’,ω + RNA + DNA – ''Francisella tularensis'' - Cryo EM<br /> |
**[[6wmr]], [[6wmt]] - FtRNAP subunits α,β,β’,ω + σ factor-binding protein PROD + starvation protein + macrophage growth locus + DNA - Cryo EM<br /> | **[[6wmr]], [[6wmt]] - FtRNAP subunits α,β,β’,ω + σ factor-binding protein PROD + starvation protein + macrophage growth locus + DNA - Cryo EM<br /> | ||
**[[6wvj]] - BsRNAP in elongation complex - Cryo EM<br /> | **[[6wvj]] - BsRNAP in elongation complex - Cryo EM<br /> | ||
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**[[7w82]] – cRNAP II - maize<br /> | **[[7w82]] – cRNAP II - maize<br /> | ||
**[[7w88]] – cRNAP II – Cryo EM<br /> | **[[7w88]] – cRNAP II – Cryo EM<br /> | ||
| - | **[[7rqs]] - AtRNAP II – Arabidopsis thaliana - Cryo EM<br /> | + | **[[7rqs]] - AtRNAP II – ''Arabidopsis thaliana'' - Cryo EM<br /> |
| - | **[[8h40]] – RNAP II + NtcA – anabaena – Cryo EM<br /> | + | **[[8h40]] – RNAP II + NtcA – ''anabaena'' – Cryo EM<br /> |
**[[1nik]], [[1nt9]], [[1wcm]], [[2b8k]], [[3fki]], [[3qt1]], [[1i3q]], [[1i50]], [[1dzf]], [[5ip7]], [[5ip9]], [[5u5q]] – yRNAP II<br /> | **[[1nik]], [[1nt9]], [[1wcm]], [[2b8k]], [[3fki]], [[3qt1]], [[1i3q]], [[1i50]], [[1dzf]], [[5ip7]], [[5ip9]], [[5u5q]] – yRNAP II<br /> | ||
**[[3j1n]], [[4v1n]], [[5fmf]], [[5x51]], [[5x50]], [[5x4z]], [[7ozo]], [[7ozp]] – yRNAP II – Cryo EM<br /> | **[[3j1n]], [[4v1n]], [[5fmf]], [[5x51]], [[5x50]], [[5x4z]], [[7ozo]], [[7ozp]] – yRNAP II – Cryo EM<br /> | ||
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**[[5vvr]] - yRNAP II + DNA + RNA + Rad26 – Cryo EM<br /> | **[[5vvr]] - yRNAP II + DNA + RNA + Rad26 – Cryo EM<br /> | ||
**[[6upx]], [[6upy]], [[6upz]], [[6uq0]], [[6uq1]], [[6uq2]], [[6uq3]], [[7rim]], [[7rip]], [[7riq]] [[7riw]], [[7rix]], [[7riy]] - yRNAP II in elongation complex<br /> | **[[6upx]], [[6upy]], [[6upz]], [[6uq0]], [[6uq1]], [[6uq2]], [[6uq3]], [[7rim]], [[7rip]], [[7riq]] [[7riw]], [[7rix]], [[7riy]] - yRNAP II in elongation complex<br /> | ||
| - | **[[ | + | **[[6inq]], [[6a5u]], [[6a5t]], [[6a5r]], [[6a5p]], [[6a5o]], [[6a5l]], [[7nkx]], [[7nky]] – yRNAP II + DNA + RNA + nucleosome – Cryo EM<br /> |
**[[7ml0]], [[7ml1]], [[7ml2]], [[7ml4]], [[7o4i]], [[7o4j]], [[7o4k]], [[7o4l]], [[7o72]], [[7o73]], [[7o75]] - yRNAP II + DNA + TFIIH + TBP – Cryo EM<br /> | **[[7ml0]], [[7ml1]], [[7ml2]], [[7ml4]], [[7o4i]], [[7o4j]], [[7o4k]], [[7o4l]], [[7o72]], [[7o73]], [[7o75]] - yRNAP II + DNA + TFIIH + TBP – Cryo EM<br /> | ||
**[[7kpv]] – yRNAP II cyclin-like subunit in Cdk8 kinase module – Cryo EM<br /> | **[[7kpv]] – yRNAP II cyclin-like subunit in Cdk8 kinase module – Cryo EM<br /> | ||
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**[[8att]], [[8atv]], [[8atw]], [[8c5s]], [[8c5u]], [[8q63]] – yRNAP in transcription initiation complex + RNA – Cryo EM<br /> | **[[8att]], [[8atv]], [[8atw]], [[8c5s]], [[8c5u]], [[8q63]] – yRNAP in transcription initiation complex + RNA – Cryo EM<br /> | ||
**[[8ap1]] – yRNAP in transcription initiation complex + GTP – Cryo EM<br /> | **[[8ap1]] – yRNAP in transcription initiation complex + GTP – Cryo EM<br /> | ||
| - | |||
*''Eukaryotic DNA primase'' | *''Eukaryotic DNA primase'' | ||
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**[[2lzn]] – SaDNAP C terminal – NMR<br /> | **[[2lzn]] – SaDNAP C terminal – NMR<br /> | ||
**[[5guj]] – BsdnaG RNAP domain <br /> | **[[5guj]] – BsdnaG RNAP domain <br /> | ||
| - | **[[6gt7]] – SiDNAP PRN1 helix bundle domain – Sulfolobus islandicus - NMR<br /> | + | **[[6gt7]] – SiDNAP PRN1 helix bundle domain – ''Sulfolobus islandicus'' - NMR<br /> |
**[[6gvu]] – SiDNAP PRN1 helix bundle domain + DNA - NMR<br /> | **[[6gvu]] – SiDNAP PRN1 helix bundle domain + DNA - NMR<br /> | ||
**[[6gvq]], [[6gvt]] – SiDNAP PRN1 helix bundle domain + DNA + ATP - NMR<br /> | **[[6gvq]], [[6gvt]] – SiDNAP PRN1 helix bundle domain + DNA + ATP - NMR<br /> | ||
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**[[4edg]], [[4edk]], [[4edr]], [[4edt]], [[4edv]], [[4ee1]] – SaDNAP + nucleotide<br /> | **[[4edg]], [[4edk]], [[4edr]], [[4edt]], [[4edv]], [[4ee1]] – SaDNAP + nucleotide<br /> | ||
**[[5of3]] - SsDNAP small + large subunit + protein<br /> | **[[5of3]] - SsDNAP small + large subunit + protein<br /> | ||
| - | **[[7uy8]] - DNAP small + large subunits + DNA polymerase α catalytic+B subunits – Tetrahymena thermophile - Cryo EM<br /> | + | **[[7uy8]] - DNAP small + large subunits + DNA polymerase α catalytic+B subunits – ''Tetrahymena thermophile'' - Cryo EM<br /> |
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**[[4chd]] – TvRNAP 627 domain <br /> | **[[4chd]] – TvRNAP 627 domain <br /> | ||
**[[4che]], [[4chf]] – TvRNAP cap-binding domain <br /> | **[[4che]], [[4chf]] – TvRNAP cap-binding domain <br /> | ||
| - | **[[5fsw]] - | + | **[[5fsw]] - RNAP C terminal – ''Thielavia terrestris''<br /> |
| - | **[[ | + | **[[6q99]] – RNAP – Andes virus<br /> |
**[[5ize]] – HavRNAP L – Hantaan virus<br /> | **[[5ize]] – HavRNAP L – Hantaan virus<br /> | ||
**[[8c4s]] – HavRNAP L – Cryo EM<br /> | **[[8c4s]] – HavRNAP L – Cryo EM<br /> | ||
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*Influenza virus polymerase acidic protein (or PA or subunit P2) N terminal 1-256; C-terminal 257-716 | *Influenza virus polymerase acidic protein (or PA or subunit P2) N terminal 1-256; C-terminal 257-716 | ||
| - | **[[2w69]], [[3ebj]], [[4p9a]], [[4nfz]], [[4avq]], [[4e5e]], [[4zqq]], [[5jht]], [[5jhv]], [[5des], [[7xgc | + | **[[2w69]], [[3ebj]], [[4p9a]], [[4nfz]], [[4avq]], [[4e5e]], [[4zqq]], [[5jht]], [[5jhv]], [[5des]], [[7xgc]] - IvRNAP PA N terminal – Influenza virus<br /> |
**[[5d2o]], [[5czn]], [[3hw6]], [[6fsb]] - IvRNAP PA N terminal (mutant) <br /> | **[[5d2o]], [[5czn]], [[3hw6]], [[6fsb]] - IvRNAP PA N terminal (mutant) <br /> | ||
**[[3hw3]], [[3hw4]], [[3hw5]] - IvRNAP PA residues N-terminal (mutant) + Mn + nucleotide <br /> | **[[3hw3]], [[3hw4]], [[3hw5]] - IvRNAP PA residues N-terminal (mutant) + Mn + nucleotide <br /> | ||
Current revision
Updated on 16-November-2023 - For a general description of the protein see RNA polymerase
