1o7x

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[[Image:1o7x.jpg|left|200px]]
 
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==Citrate synthase from Sulfolobus solfataricus==
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The line below this paragraph, containing "STRUCTURE_1o7x", creates the "Structure Box" on the page.
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<StructureSection load='1o7x' size='340' side='right'caption='[[1o7x]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1o7x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O7X FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7x OCA], [https://pdbe.org/1o7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o7x RCSB], [https://www.ebi.ac.uk/pdbsum/1o7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o7x ProSAT]</span></td></tr>
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{{STRUCTURE_1o7x| PDB=1o7x | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CISY_SACS2 CISY_SACS2]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o7/1o7x_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o7x ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of citrate synthase from the thermophilic Archaeon Sulfolobus solfataricus (optimum growth temperature = 85 degrees C) has been determined, extending the number of crystal structures of citrate synthase from different organisms to a total of five that span the temperature range over which life exists (from psychrophile to hyperthermophile). Detailed structural analysis has revealed possible molecular mechanisms that determine the different stabilities of the five proteins. The key to these mechanisms is the precise structural location of the additional interactions. As one ascends the temperature ladder, the subunit interface of this dimeric enzyme and loop regions are reinforced by complex electrostatic interactions, and there is a reduced exposure of hydrophobic surface. These observations reveal a progressive pattern of stabilization through multiple additional interactions at solvent exposed, loop and interfacial regions.
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'''CITRATE SYNTHASE FROM SULFOLOBUS SOLFATARICUS'''
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Stepwise adaptations of citrate synthase to survival at life's extremes. From psychrophile to hyperthermophile.,Bell GS, Russell RJ, Connaris H, Hough DW, Danson MJ, Taylor GL Eur J Biochem. 2002 Dec;269(24):6250-60. PMID:12473121<ref>PMID:12473121</ref>
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==Overview==
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The crystal structure of citrate synthase from the thermophilic Archaeon Sulfolobus solfataricus (optimum growth temperature = 85 degrees C) has been determined, extending the number of crystal structures of citrate synthase from different organisms to a total of five that span the temperature range over which life exists (from psychrophile to hyperthermophile). Detailed structural analysis has revealed possible molecular mechanisms that determine the different stabilities of the five proteins. The key to these mechanisms is the precise structural location of the additional interactions. As one ascends the temperature ladder, the subunit interface of this dimeric enzyme and loop regions are reinforced by complex electrostatic interactions, and there is a reduced exposure of hydrophobic surface. These observations reveal a progressive pattern of stabilization through multiple additional interactions at solvent exposed, loop and interfacial regions.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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1O7X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7X OCA].
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</div>
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<div class="pdbe-citations 1o7x" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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Stepwise adaptations of citrate synthase to survival at life's extremes. From psychrophile to hyperthermophile., Bell GS, Russell RJ, Connaris H, Hough DW, Danson MJ, Taylor GL, Eur J Biochem. 2002 Dec;269(24):6250-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12473121 12473121]
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*[[Citrate Synthase 3D structures|Citrate Synthase 3D structures]]
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[[Category: Single protein]]
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== References ==
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[[Category: Sulfolobus solfataricus]]
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<references/>
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[[Category: Bell, G S.]]
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__TOC__
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[[Category: Connaris, H.]]
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</StructureSection>
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[[Category: Danson, M J.]]
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[[Category: Large Structures]]
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[[Category: Hough, D W.]]
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[[Category: Saccharolobus solfataricus]]
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[[Category: Russell, R J.M.]]
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[[Category: Bell GS]]
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[[Category: Taylor, G L.]]
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[[Category: Connaris H]]
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[[Category: Lyase]]
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[[Category: Danson MJ]]
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[[Category: Tricarboxylic acid cycle]]
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[[Category: Hough DW]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:29:58 2008''
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[[Category: Russell RJM]]
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[[Category: Taylor GL]]

Current revision

Citrate synthase from Sulfolobus solfataricus

PDB ID 1o7x

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