8uwp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "8uwp" [edit=sysop:move=sysop])
Current revision (09:11, 4 June 2025) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8uwp is ON HOLD
+
==Crystal structure of SETDB1 Tudor domain in complex with MR46747==
-
 
+
<StructureSection load='8uwp' size='340' side='right'caption='[[8uwp]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
-
Authors: Shrestha, S., Beldar, S., Dong, A., Ackloo, S., Brown, P.J., Arrowsmith, C.H., Edwards, A.M., Halabelian, L., Structural Genomics Consortium (SGC)
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8uwp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UWP FirstGlance]. <br>
-
Description: Crystal structure of SETDB1 Tudor domain in complex with MR43625
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XRU:(3~{S})-~{N}-[4-chloranyl-3-[2-(diethylamino)ethylcarbamoyl]phenyl]-3-(diethylamino)pyrrolidine-1-carboxamide'>XRU</scene></td></tr>
-
[[Category: Shrestha, S]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uwp OCA], [https://pdbe.org/8uwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uwp RCSB], [https://www.ebi.ac.uk/pdbsum/8uwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uwp ProSAT]</span></td></tr>
-
[[Category: Edwards, A.M]]
+
</table>
-
[[Category: Arrowsmith, C.H]]
+
== Function ==
-
[[Category: Dong, A]]
+
[https://www.uniprot.org/uniprot/SETB1_HUMAN SETB1_HUMAN] Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.<ref>PMID:12869583</ref> <ref>PMID:14536086</ref> <ref>PMID:15327775</ref> <ref>PMID:17952062</ref>
-
[[Category: Structural Genomics Consortium (Sgc)]]
+
== References ==
-
[[Category: Halabelian, L]]
+
<references/>
-
[[Category: Brown, P.J]]
+
__TOC__
-
[[Category: Beldar, S]]
+
</StructureSection>
-
[[Category: Ackloo, S]]
+
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Ackloo S]]
 +
[[Category: Arrowsmith CH]]
 +
[[Category: Beldar S]]
 +
[[Category: Brown PJ]]
 +
[[Category: Dong A]]
 +
[[Category: Edwards AM]]
 +
[[Category: Halabelian L]]
 +
[[Category: Shrestha S]]

Current revision

Crystal structure of SETDB1 Tudor domain in complex with MR46747

PDB ID 8uwp

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8uwp"
Personal tools