8ewt

Structural highlights

Function

CBH_LACGA Bile salt hydrolase that catalyzes the deconjugation of glycine- and taurine-linked bile salts, which occurs naturally in the intestines of humans, releasing amino acid residues and deconjugated bile salts (bile acids) (PubMed:34066735). Can hydrolyze the amide bond in the bile salts taurocholate (TCA), taurodeoxycholate (TDCA), taurochenodeoxycholate (TCDCA), glycocholate (GCA) and glycodeoxycholate (GDCA) (PubMed:34066735). Shows highest activity toward the taurine-conjugated bile salts TCA and TCDCA (PubMed:34066735). The activity toward the other three substrates (TDCA, GCA and GDCA) is relatively low (PubMed:34066735). This enzyme likely contributes to bile salt resistance of the strain and may be associated with survival capability of strain JCM1131 within the human intestine by bile detoxification (PubMed:34066735).^[1]

References

1. ↑ Kusada H, Morinaga K, Tamaki H. Identification of Bile Salt Hydrolase and Bile Salt Resistance in a Probiotic Bacterium Lactobacillus gasseri JCM1131(T). Microorganisms. 2021 May 8;9(5):1011. PMID:34066735 doi:10.3390/microorganisms9051011