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== Function == | == Function == | ||
| - | [https://www.uniprot.org/uniprot/ | + | [https://www.uniprot.org/uniprot/CBH_LACGA CBH_LACGA] Bile salt hydrolase that catalyzes the deconjugation of glycine- and taurine-linked bile salts, which occurs naturally in the intestines of humans, releasing amino acid residues and deconjugated bile salts (bile acids) (PubMed:34066735). Can hydrolyze the amide bond in the bile salts taurocholate (TCA), taurodeoxycholate (TDCA), taurochenodeoxycholate (TCDCA), glycocholate (GCA) and glycodeoxycholate (GDCA) (PubMed:34066735). Shows highest activity toward the taurine-conjugated bile salts TCA and TCDCA (PubMed:34066735). The activity toward the other three substrates (TDCA, GCA and GDCA) is relatively low (PubMed:34066735). This enzyme likely contributes to bile salt resistance of the strain and may be associated with survival capability of strain JCM1131 within the human intestine by bile detoxification (PubMed:34066735).<ref>PMID:34066735</ref> |
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Bile salt hydrolase A from Lactobacillus gasseri bound to covalent probe
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