This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1pcf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /> <applet load="1pcf" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pcf, resolution 1.74&Aring;" /> '''HUMAN TRANSCRIPTION...)
Current revision (08:06, 14 February 2024) (edit) (undo)
 
(15 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1pcf.gif|left|200px]]<br />
 
-
<applet load="1pcf" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1pcf, resolution 1.74&Aring;" />
 
-
'''HUMAN TRANSCRIPTIONAL COACTIVATOR PC4 C-TERMINAL DOMAIN'''<br />
 
-
==Overview==
+
==HUMAN TRANSCRIPTIONAL COACTIVATOR PC4 C-TERMINAL DOMAIN==
-
The crystal structure of human replication and transcription cofactor, PC4CTD reveals a dimer with two single-stranded (ss)DNA binding channels, running in opposite directions to each other. This arrangement suggests a, role in establishment or maintenance of melted DNA at promoters or origins, of replication.
+
<StructureSection load='1pcf' size='340' side='right'caption='[[1pcf]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[1pcf]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PCF FirstGlance]. <br>
-
1PCF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1PCF OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pcf OCA], [https://pdbe.org/1pcf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pcf RCSB], [https://www.ebi.ac.uk/pdbsum/1pcf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pcf ProSAT]</span></td></tr>
-
==Reference==
+
</table>
-
C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site., Brandsen J, Werten S, van der Vliet PC, Meisterernst M, Kroon J, Gros P, Nat Struct Biol. 1997 Nov;4(11):900-3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9360603 9360603]
+
== Function ==
 +
[https://www.uniprot.org/uniprot/TCP4_HUMAN TCP4_HUMAN] General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).<ref>PMID:8062392</ref> <ref>PMID:8062391</ref> <ref>PMID:7628453</ref> <ref>PMID:9482861</ref> <ref>PMID:16689930</ref> <ref>PMID:9360603</ref> <ref>PMID:16605275</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pc/1pcf_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pcf ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Brandsen, J.]]
+
[[Category: Brandsen J]]
-
[[Category: Gros, P.]]
+
[[Category: Gros P]]
-
[[Category: nuclear protein]]
+
-
[[Category: ssdna binding]]
+
-
[[Category: transcription]]
+
-
[[Category: transcriptional co-activator]]
+
-
[[Category: transcriptional cofactor]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 18:42:05 2007''
+

Current revision

HUMAN TRANSCRIPTIONAL COACTIVATOR PC4 C-TERMINAL DOMAIN

PDB ID 1pcf

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pcf"
Personal tools