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| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zjx OCA], [https://pdbe.org/7zjx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zjx RCSB], [https://www.ebi.ac.uk/pdbsum/7zjx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zjx ProSAT]</span></td></tr> | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zjx OCA], [https://pdbe.org/7zjx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zjx RCSB], [https://www.ebi.ac.uk/pdbsum/7zjx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zjx ProSAT]</span></td></tr> |
| | </table> | | </table> |
| - | == Disease == | |
| - | [https://www.uniprot.org/uniprot/SEBP2_HUMAN SEBP2_HUMAN] Short stature-delayed bone age due to thyroid hormone metabolism deficiency. The disease is caused by variants affecting the gene represented in this entry. | |
| | == Function == | | == Function == |
| - | [https://www.uniprot.org/uniprot/SEBP2_HUMAN SEBP2_HUMAN] Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB. | + | [https://www.uniprot.org/uniprot/A0A7J8BG50_ROUAE A0A7J8BG50_ROUAE] |
| - | <div style="background-color:#fffaf0;">
| + | |
| - | == Publication Abstract from PubMed ==
| + | |
| - | The elongation of eukaryotic selenoproteins relies on a poorly understood process of interpreting in-frame UGA stop codons as selenocysteine (Sec). We used cryo-electron microscopy to visualize Sec UGA recoding in mammals. A complex between the noncoding Sec-insertion sequence (SECIS), SECIS-binding protein 2 (SBP2), and 40S ribosomal subunit enables Sec-specific elongation factor eEFSec to deliver Sec. eEFSec and SBP2 do not interact directly but rather deploy their carboxyl-terminal domains to engage with the opposite ends of the SECIS. By using its Lys-rich and carboxyl-terminal segments, the ribosomal protein eS31 simultaneously interacts with Sec-specific transfer RNA (tRNA(Sec)) and SBP2, which further stabilizes the assembly. eEFSec is indiscriminate toward l-serine and facilitates its misincorporation at Sec UGA codons. Our results support a fundamentally distinct mechanism of Sec UGA recoding in eukaryotes from that in bacteria.
| + | |
| - | | + | |
| - | Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon.,Hilal T, Killam BY, Grozdanovic M, Dobosz-Bartoszek M, Loerke J, Burger J, Mielke T, Copeland PR, Simonovic M, Spahn CMT Science. 2022 Jun 17;376(6599):1338-1343. doi: 10.1126/science.abg3875. Epub 2022, Jun 16. PMID:35709277<ref>PMID:35709277</ref>
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| - | | + | |
| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
| + | |
| - | </div>
| + | |
| - | <div class="pdbe-citations 7zjx" style="background-color:#fffaf0;"></div>
| + | |
| | | | |
| | ==See Also== | | ==See Also== |
| | *[[Ribosome 3D structures|Ribosome 3D structures]] | | *[[Ribosome 3D structures|Ribosome 3D structures]] |
| - | == References == | |
| - | <references/> | |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| Structural highlights
7zjx is a 10 chain structure with sequence from Cricket paralysis virus, Homo sapiens and Oryctolagus cuniculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Method: | Electron Microscopy, Resolution 3.1Å |
| Ligands: | , , , , , , , , , , , , , , , , , , , , , , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
A0A7J8BG50_ROUAE
See Also
|
