1oaq

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[[Image:1oaq.jpg|left|200px]]
 
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==Free conformation Ab1 of the IgE SPE-7==
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The line below this paragraph, containing "STRUCTURE_1oaq", creates the "Structure Box" on the page.
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<StructureSection load='1oaq' size='340' side='right'caption='[[1oaq]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1oaq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OAQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oaq OCA], [https://pdbe.org/1oaq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oaq RCSB], [https://www.ebi.ac.uk/pdbsum/1oaq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oaq ProSAT]</span></td></tr>
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{{STRUCTURE_1oaq| PDB=1oaq | SCENE= }}
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</table>
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== Function ==
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'''FREE CONFORMATION AB1 OF THE IGE SPE-7'''
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[https://www.uniprot.org/uniprot/LV1B_MOUSE LV1B_MOUSE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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A single antibody was shown to adopt different binding-site conformations and thereby bind unrelated antigens. Analysis by both x-ray crystallography and pre-steady-state kinetics revealed an equilibrium between different preexisting isomers, one of which possessed a promiscuous, low-affinity binding site for aromatic ligands, including the immunizing hapten. A subsequent induced-fit isomerization led to high-affinity complexes with a deep and narrow binding site. A protein antigen identified by repertoire selection made use of an unrelated antibody isomer with a wide, shallow binding site. Conformational diversity, whereby one sequence adopts multiple structures and multiple functions, can increase the effective size of the antibody repertoire but may also lead to autoimmunity and allergy.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oa/1oaq_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1OAQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAQ OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oaq ConSurf].
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Antibody multispecificity mediated by conformational diversity., James LC, Roversi P, Tawfik DS, Science. 2003 Feb 28;299(5611):1362-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12610298 12610298]
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<div style="clear:both"></div>
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[[Category: Rattus rattus]]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: James, L C.]]
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[[Category: Large Structures]]
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[[Category: Roversi, P.]]
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[[Category: Mus musculus]]
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[[Category: Tawfik, D.]]
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[[Category: James LC]]
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[[Category: Allergy]]
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[[Category: Roversi P]]
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[[Category: Antibody]]
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[[Category: Tawfik D]]
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[[Category: Conformational diversity]]
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[[Category: Ige]]
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[[Category: Multispecificity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:36:21 2008''
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Current revision

Free conformation Ab1 of the IgE SPE-7

PDB ID 1oaq

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