1ob4

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[[Image:1ob4.jpg|left|200px]]
 
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==Cephaibol A==
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The line below this paragraph, containing "STRUCTURE_1ob4", creates the "Structure Box" on the page.
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<StructureSection load='1ob4' size='340' side='right'caption='[[1ob4]], [[Resolution|resolution]] 0.95&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ob4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acremonium_tubakii Acremonium tubakii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OB4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=DIV:D-ISOVALINE'>DIV</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=PHL:L-PHENYLALANINOL'>PHL</scene>, <scene name='pdbligand=PRD_000156:Cephaibol+A'>PRD_000156</scene></td></tr>
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{{STRUCTURE_1ob4| PDB=1ob4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ob4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ob4 OCA], [https://pdbe.org/1ob4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ob4 RCSB], [https://www.ebi.ac.uk/pdbsum/1ob4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ob4 ProSAT]</span></td></tr>
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</table>
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'''CEPHAIBOL A'''
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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==Overview==
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The crystal structures of the peptaibol antibiotics cephaibol A, cephaibol B and cephaibol C have been determined at ca. 0.9 A resolution. All three adopt a helical conformation with a sharp bend (of about 55 degrees) at the central hydroxyproline. All isovalines were found to possess the D configuration, superposition of all four models (there are two independent molecules in the cephaibol B structure) shows that the N-terminal helix is rigid and the C-terminus is flexible. There are differences in the hydrogen bonding patterns for the three structures that crystallize in different space groups despite relatively similar unit cell dimensions, but only in the case of cephaibol C does the packing emulate the formation of a membrane channel believed to be important for their biological function.
The crystal structures of the peptaibol antibiotics cephaibol A, cephaibol B and cephaibol C have been determined at ca. 0.9 A resolution. All three adopt a helical conformation with a sharp bend (of about 55 degrees) at the central hydroxyproline. All isovalines were found to possess the D configuration, superposition of all four models (there are two independent molecules in the cephaibol B structure) shows that the N-terminal helix is rigid and the C-terminus is flexible. There are differences in the hydrogen bonding patterns for the three structures that crystallize in different space groups despite relatively similar unit cell dimensions, but only in the case of cephaibol C does the packing emulate the formation of a membrane channel believed to be important for their biological function.
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==About this Structure==
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Crystal structures of cephaibols.,Bunkoczi G, Schiell M, Vertesy L, Sheldrick GM J Pept Sci. 2003 Nov-Dec;9(11-12):745-52. PMID:14658793<ref>PMID:14658793</ref>
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1OB4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Acremonium_tubakii Acremonium tubakii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OB4 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Crystal structures of cephaibols., Bunkoczi G, Schiell M, Vertesy L, Sheldrick GM, J Pept Sci. 2003 Nov-Dec;9(11-12):745-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14658793 14658793]
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</div>
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<div class="pdbe-citations 1ob4" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Acremonium tubakii]]
[[Category: Acremonium tubakii]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bunkoczi, G.]]
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[[Category: Bunkoczi G]]
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[[Category: Schiell, M.]]
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[[Category: Schiell M]]
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[[Category: Sheldrick, G M.]]
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[[Category: Sheldrick GM]]
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[[Category: Vertesy, L.]]
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[[Category: Vertesy L]]
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[[Category: Antibiotic]]
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[[Category: Cephaibol]]
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[[Category: Ion channel]]
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[[Category: Peptaibol]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:37:04 2008''
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Current revision

Cephaibol A

PDB ID 1ob4

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