8wvt
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Lsd18 in complex with ligands== | |
| - | + | <StructureSection load='8wvt' size='340' side='right'caption='[[8wvt]], [[Resolution|resolution]] 1.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8wvt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_lasalocidi Streptomyces lasalocidi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WVT FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1LWM:4-methyl-5-phenyl-3-[(2~{R},3~{S},4~{S},6~{E},10~{E})-2,6,10-triethyl-4-methyl-3-oxidanyl-dodeca-6,10-dienoyl]-1,3-oxazolidin-2-one'>A1LWM</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=ELY:N~6~,N~6~-DIETHYL-L-LYSINE'>ELY</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=X9E:3-[(~{Z})-2,6-diethyl-9-[(2~{R},3~{R})-2-ethyl-3-methyl-oxiran-2-yl]-4-methyl-3-oxidanyl-non-6-enoyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one'>X9E</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wvt OCA], [https://pdbe.org/8wvt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wvt RCSB], [https://www.ebi.ac.uk/pdbsum/8wvt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wvt ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LSD18_STRLS LSD18_STRLS] May catalyze the stereoselective double epoxidation reaction leading to bisepoxyprelasalocid A, a bisepoxide intermediate in the biosynthesis of the polyether antibiotic lasalocid A.<ref>PMID:19025863</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Streptomyces lasalocidi]] | ||
| + | [[Category: Chen X]] | ||
| + | [[Category: Deng YM]] | ||
| + | [[Category: Hu YL]] | ||
Current revision
Crystal structure of Lsd18 in complex with ligands
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