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1pgr
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="1pgr" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pgr, resolution 3.5Å" /> '''2:2 COMPLEX OF G-CSF...) |
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| - | [[Image:1pgr.gif|left|200px]]<br /> | ||
| - | <applet load="1pgr" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1pgr, resolution 3.5Å" /> | ||
| - | '''2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR'''<br /> | ||
| - | == | + | ==2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR== |
| - | Granulocyte colony-stimulating factor (GCSF) is the principal growth | + | <StructureSection load='1pgr' size='340' side='right'caption='[[1pgr]], [[Resolution|resolution]] 3.50Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1pgr]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PGR FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pgr OCA], [https://pdbe.org/1pgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pgr RCSB], [https://www.ebi.ac.uk/pdbsum/1pgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pgr ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CSF3_HUMAN CSF3_HUMAN] Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pg/1pgr_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pgr ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Granulocyte colony-stimulating factor (GCSF) is the principal growth factor regulating the maturation, proliferation and differentiation of the precursor cells of neutrophilic granulocytes and is used to treat neutropenia. GCSF is a member of the long-chain subtype of the class 1 cytokine superfamily, which includes growth hormone, erythropoietin, interleukin 6 and oncostatin M. Here we have determined the crystal structure of GCSF complexed to the BN-BC domains, the principal ligand-binding region of the GCSF receptor (GCSFR). The two receptor domains form a complex in a 2:2 ratio with the ligand, with a non-crystallographic pseudo-twofold axis through primarily the interdomain region and secondarily the BC domain. This structural view of a gp130-type receptor-ligand complex presents a new molecular basis for cytokine-receptor recognition. | ||
| - | + | Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme.,Aritomi M, Kunishima N, Okamoto T, Kuroki R, Ota Y, Morikawa K Nature. 1999 Oct 14;401(6754):713-7. PMID:10537111<ref>PMID:10537111</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | <div class="pdbe-citations 1pgr" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Colony-stimulating factor 3D structures|Colony-stimulating factor 3D structures]] | ||
| + | *[[Colony-stimulating factor receptor 3D structures|Colony-stimulating factor receptor 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | + | [[Category: Aritomi M]] | |
| - | [[Category: Aritomi | + | [[Category: Kunishima N]] |
| - | [[Category: Kunishima | + | [[Category: Kuroki R]] |
| - | [[Category: Kuroki | + | [[Category: Morikawa K]] |
| - | [[Category: Morikawa | + | [[Category: Okamoto T]] |
| - | [[Category: Okamoto | + | [[Category: Ota Y]] |
| - | [[Category: Ota | + | |
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Current revision
2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR
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Categories: Homo sapiens | Large Structures | Mus musculus | Aritomi M | Kunishima N | Kuroki R | Morikawa K | Okamoto T | Ota Y
