1pkt

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(New page: 200px<br /> <applet load="1pkt" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pkt" /> '''STRUCTURE OF THE PI3K SH3 DOMAIN AND ANALYS...)
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[[Image:1pkt.gif|left|200px]]<br />
 
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<applet load="1pkt" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1pkt" />
 
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'''STRUCTURE OF THE PI3K SH3 DOMAIN AND ANALYSIS OF THE SH3 FAMILY'''<br />
 
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==Overview==
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==STRUCTURE OF THE PI3K SH3 DOMAIN AND ANALYSIS OF THE SH3 FAMILY==
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Src homology 3 (SH3) domains, which are found in many proteins involved in, intracellular signal transduction, mediate specific protein-protein, interactions. The three-dimensional structure of the SH3 domain in the p85, subunit of the phosphatidylinositol 3-kinase (PI3K) has been determined by, multidimensional NMR methods. The molecule consists of four short helices, two beta turns, and two antiparallel beta sheets. The beta sheets are, highly similar to corresponding regions in the SH3 domain of the tyrosine, kinase Src, even though the sequence identity of the two domains is low., There is a unique 15 amino acid insert in PI3K that contains three short, helices. There are substantial differences in the identity of the amino, acids that make up the receptor site of SH3 domains. The results suggest, that while the overall structures of the binding sites in the PI3K and Src, SH3 domains are similar, their ligand binding properties may differ.
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<StructureSection load='1pkt' size='340' side='right'caption='[[1pkt]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1pkt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PKT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pkt OCA], [https://pdbe.org/1pkt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pkt RCSB], [https://www.ebi.ac.uk/pdbsum/1pkt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pkt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P85A_HUMAN P85A_HUMAN] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.<ref>PMID:7518429</ref> <ref>PMID:17626883</ref> <ref>PMID:19805105</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pk/1pkt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pkt ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1PKT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1PKT OCA].
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*[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]]
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== References ==
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==Reference==
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<references/>
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Structure of the PI3K SH3 domain and analysis of the SH3 family., Koyama S, Yu H, Dalgarno DC, Shin TB, Zydowsky LD, Schreiber SL, Cell. 1993 Mar 26;72(6):945-52. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7681364 7681364]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphatidylinositol 3-kinase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Dalgarno DC]]
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[[Category: Dalgarno, D.C.]]
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[[Category: Koyama S]]
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[[Category: Koyama, S.]]
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[[Category: Schreiber SL]]
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[[Category: Schreiber, S.L.]]
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[[Category: Shin TB]]
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[[Category: Shin, T.B.]]
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[[Category: Yu H]]
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[[Category: Yu, H.]]
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[[Category: Zydowsky LD]]
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[[Category: Zydowsky, L.D.]]
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[[Category: phosphotransferase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 18:44:16 2007''
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STRUCTURE OF THE PI3K SH3 DOMAIN AND ANALYSIS OF THE SH3 FAMILY

PDB ID 1pkt

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