1oht

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[[Image:1oht.gif|left|200px]]
 
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==Peptidoglycan recognition protein LB==
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The line below this paragraph, containing "STRUCTURE_1oht", creates the "Structure Box" on the page.
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<StructureSection load='1oht' size='340' side='right'caption='[[1oht]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1oht]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OHT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OHT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1oht| PDB=1oht | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oht OCA], [https://pdbe.org/1oht PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oht RCSB], [https://www.ebi.ac.uk/pdbsum/1oht PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oht ProSAT]</span></td></tr>
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</table>
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'''PEPTIDOGLYCAN RECOGNITION PROTEIN-LB'''
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== Function ==
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[https://www.uniprot.org/uniprot/PGPLB_DROME PGPLB_DROME] N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity.<ref>PMID:12845326</ref>
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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The family of peptidoglycan recognition proteins (PGRPs) are associated with the recognition of the peptidoglycan of microbes and subsequent activation of signaling pathways for immune response. Here the crystal structure of Drosophila PGRP-LB is determined at a resolution of 2.0 A and shows an active-site cleft with a zinc cage. Poor conservation of surface residues at the cleft predicts a widely varying individual specificity of PGRPs for molecular patterns on microbial cell walls. At the back of this cleft is a putatively conserved distinctive groove. The location and mainly hydrophobic nature of the groove indicate that the back face serves for subsequent signaling after clustering of PGRP molecules by binding to polymeric cell wall components.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oh/1oht_consurf.spt"</scriptWhenChecked>
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1OHT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OHT OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Crystal structure of peptidoglycan recognition protein LB from Drosophila melanogaster., Kim MS, Byun M, Oh BH, Nat Immunol. 2003 Aug;4(8):787-93. Epub 2003 Jul 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12845326 12845326]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oht ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Byun, M.]]
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[[Category: Byun M]]
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[[Category: Kim, M S.]]
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[[Category: Kim M-S]]
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[[Category: Oh, B H.]]
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[[Category: Oh B-H]]
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[[Category: Hydrolase]]
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[[Category: Peptidoglycan-recognition protein-lb isoform 2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:51:49 2008''
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Current revision

Peptidoglycan recognition protein LB

PDB ID 1oht

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