8oif
From Proteopedia
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- | '''Unreleased structure''' | ||
- | + | ==Structure of the UBE1L activating enzyme bound to ISG15 and UBE2L6== | |
+ | <StructureSection load='8oif' size='340' side='right'caption='[[8oif]], [[Resolution|resolution]] 3.50Å' scene=''> | ||
+ | == Structural highlights == | ||
+ | <table><tr><td colspan='2'>[[8oif]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OIF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OIF FirstGlance]. <br> | ||
+ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5Å</td></tr> | ||
+ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr> | ||
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8oif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8oif OCA], [https://pdbe.org/8oif PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8oif RCSB], [https://www.ebi.ac.uk/pdbsum/8oif PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8oif ProSAT]</span></td></tr> | ||
+ | </table> | ||
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/UBA7_HUMAN UBA7_HUMAN] E1-activating enzyme that catalyzes the covalent conjugation of the ubiquitin-like protein product of ISG15 to additional interferon stimulated proteins (ISGs) as well as other cellular proteins such as P53 in a process termed protein ISGylation (PubMed:27545325). Plays an essential role in antiviral immunity together with ISG15 by restricting the replication of many viruses including rabies virus, influenza virus, sindbis virus, rotavirus or human cytomegalovirus (PubMed:16254333, PubMed:19073728, PubMed:29056542, PubMed:29743376, PubMed:37722521). For example, ISG15 modification of influenza A protein NS1 disrupts the association of the NS1 with importin-alpha leading to NS1 nuclear import inhibition (PubMed:20133869). ISGylation of human cytomegalovirs protein UL26 regulates its stability and inhibits its activities to suppress NF-kappa-B signaling (PubMed:27564865).<ref>PMID:16254333</ref> <ref>PMID:19073728</ref> <ref>PMID:20133869</ref> <ref>PMID:27545325</ref> <ref>PMID:27564865</ref> <ref>PMID:29056542</ref> <ref>PMID:29743376</ref> <ref>PMID:37722521</ref> | ||
- | + | ==See Also== | |
- | + | *[[3D structures of Ubiquitin activating enzyme|3D structures of Ubiquitin activating enzyme]] | |
- | + | == References == | |
- | [[Category: | + | <references/> |
+ | __TOC__ | ||
+ | </StructureSection> | ||
+ | [[Category: Homo sapiens]] | ||
+ | [[Category: Large Structures]] | ||
+ | [[Category: Kheewoong B]] | ||
+ | [[Category: Prabu JR]] | ||
+ | [[Category: Schulman BA]] | ||
+ | [[Category: Swatek KN]] | ||
+ | [[Category: Vollrath R]] | ||
+ | [[Category: Wallace I]] | ||
+ | [[Category: Von Gronau S]] |
Current revision
Structure of the UBE1L activating enzyme bound to ISG15 and UBE2L6
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