8r6g
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==A quadruplex-duplex hybrid with a three-layered chair G-quadruplex topology== | |
| + | <StructureSection load='8r6g' size='340' side='right'caption='[[8r6g]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8r6g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8R6G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8R6G FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1H3G:2-DEOXYADENOSINE-5-MONOPHOSPHATE+(protonated+at+N1)'>A1H3G</scene>, <scene name='pdbligand=BGM:8-BROMO-2-DEOXYGUANOSINE-5-MONOPHOSPHATE'>BGM</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8r6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8r6g OCA], [https://pdbe.org/8r6g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8r6g RCSB], [https://www.ebi.ac.uk/pdbsum/8r6g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8r6g ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Quadruplex-duplex (QD) junctions, which represent unique structural motifs of both biological and technological significance, have been shown to constitute high-affinity binding sites for various ligands. A QD hybrid construct based on a human telomeric sequence, which harbors a duplex stem-loop in place of a short lateral loop, is structurally characterized by NMR. It folds into two major species with a (3+1) hybrid and a chair-type (2+2) antiparallel quadruplex domain coexisting in a K(+) buffer solution. The antiparallel species is stabilized by an unusual capping structure involving a thymine and protonated adenine base AH(+) of the lateral loop facing the hairpin duplex to form a T.AH(+).G.C quartet with the interfacial G.C base pair at neutral pH. Addition and binding of Phen-DC(3) to the QD hybrid mixture by its partial intercalation at corresponding QD junctions leads to a topological transition with exclusive formation of the (3+1) hybrid fold. In agreement with the available experimental data, such an unprecedented discrimination of QD junctions by a ligand can be rationalized following an induced fit mechanism. | ||
| - | + | Structural Differences at Quadruplex-Duplex Interfaces Enable Ligand-Induced Topological Transitions.,Vianney YM, Dierks D, Weisz K Adv Sci (Weinh). 2024 Jun;11(24):e2309891. doi: 10.1002/advs.202309891. Epub 2024 , Mar 13. PMID:38477454<ref>PMID:38477454</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 8r6g" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Vianney YM]] | ||
| + | [[Category: Weisz K]] | ||
Current revision
A quadruplex-duplex hybrid with a three-layered chair G-quadruplex topology
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