This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
8v15
From Proteopedia
(Difference between revisions)
m (Protected "8v15" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Human SIRT3 bound to p53-AMC peptide, Carba-NAD, and Honokiol== | |
| - | + | <StructureSection load='8v15' size='340' side='right'caption='[[8v15]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8v15]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8V15 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8V15 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CNA:CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>CNA</scene>, <scene name='pdbligand=FDL:N~6~-ACETYL-N-(4-METHYL-2-OXO-2H-CHROMEN-7-YL)-L-LYSINAMIDE'>FDL</scene>, <scene name='pdbligand=Y4T:(1P)-3,5-di(prop-2-en-1-yl)[1,1-biphenyl]-2,4-diol'>Y4T</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8v15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8v15 OCA], [https://pdbe.org/8v15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8v15 RCSB], [https://www.ebi.ac.uk/pdbsum/8v15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8v15 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/SIR3_HUMAN SIR3_HUMAN] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.<ref>PMID:16788062</ref> <ref>PMID:18680753</ref> <ref>PMID:18794531</ref> <ref>PMID:19535340</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: Guan | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Roy | + | [[Category: Chakrabarti R]] |
| - | [[Category: | + | [[Category: Chall S]] |
| + | [[Category: Delacroix T]] | ||
| + | [[Category: Dumpati RK]] | ||
| + | [[Category: Errasti G]] | ||
| + | [[Category: Ghosh A]] | ||
| + | [[Category: Guan X]] | ||
| + | [[Category: Munshi S]] | ||
| + | [[Category: Rahnamoun A]] | ||
| + | [[Category: Reverdy C]] | ||
| + | [[Category: Roy S]] | ||
| + | [[Category: Upadhyay A]] | ||
Current revision
Human SIRT3 bound to p53-AMC peptide, Carba-NAD, and Honokiol
| |||||||||||
Categories: Homo sapiens | Large Structures | Chakrabarti R | Chall S | Delacroix T | Dumpati RK | Errasti G | Ghosh A | Guan X | Munshi S | Rahnamoun A | Reverdy C | Roy S | Upadhyay A
