1ojg

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[[Image:1ojg.jpg|left|200px]]
 
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==Sensory domain of the membraneous two-component fumarate sensor DcuS of E. coli==
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The line below this paragraph, containing "STRUCTURE_1ojg", creates the "Structure Box" on the page.
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<StructureSection load='1ojg' size='340' side='right'caption='[[1ojg]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ojg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OJG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OJG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ojg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ojg OCA], [https://pdbe.org/1ojg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ojg RCSB], [https://www.ebi.ac.uk/pdbsum/1ojg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ojg ProSAT]</span></td></tr>
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{{STRUCTURE_1ojg| PDB=1ojg | SCENE= }}
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</table>
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== Function ==
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'''SENSORY DOMAIN OF THE MEMBRANEOUS TWO-COMPONENT FUMARATE SENSOR DCUS OF E. COLI'''
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[https://www.uniprot.org/uniprot/DCUS_ECOLI DCUS_ECOLI] Member of the two-component regulatory system DcuR/DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4-dicarboxylate transporter dctA. Activates DcuR by phosphorylation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oj/1ojg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ojg ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
The structure of the water-soluble, periplasmic domain of the fumarate sensor DcuS (DcuS-pd) has been determined by NMR spectroscopy in solution. DcuS is a prototype for a sensory histidine kinase with transmembrane signal transfer. DcuS belongs to the CitA family of sensors that are specific for sensing di- and tricarboxylates. The periplasmic domain is folded autonomously and shows helices at the N and the C terminus, suggesting direct linking or connection to helices in the two transmembrane regions. The structure constitutes a novel fold. The nearest structural neighbor is the Per-Arnt-Sim domain of the photoactive yellow protein that binds small molecules covalently. Residues Arg107, His110, and Arg147 are essential for fumarate sensing and are found clustered together. The structure constitutes the first periplasmic domain of a two component sensory system and is distinctly different from the aspartate sensory domain of the Tar chemotaxis sensor.
The structure of the water-soluble, periplasmic domain of the fumarate sensor DcuS (DcuS-pd) has been determined by NMR spectroscopy in solution. DcuS is a prototype for a sensory histidine kinase with transmembrane signal transfer. DcuS belongs to the CitA family of sensors that are specific for sensing di- and tricarboxylates. The periplasmic domain is folded autonomously and shows helices at the N and the C terminus, suggesting direct linking or connection to helices in the two transmembrane regions. The structure constitutes a novel fold. The nearest structural neighbor is the Per-Arnt-Sim domain of the photoactive yellow protein that binds small molecules covalently. Residues Arg107, His110, and Arg147 are essential for fumarate sensing and are found clustered together. The structure constitutes the first periplasmic domain of a two component sensory system and is distinctly different from the aspartate sensory domain of the Tar chemotaxis sensor.
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==About this Structure==
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The NMR structure of the sensory domain of the membranous two-component fumarate sensor (histidine protein kinase) DcuS of Escherichia coli.,Pappalardo L, Janausch IG, Vijayan V, Zientz E, Junker J, Peti W, Zweckstetter M, Unden G, Griesinger C J Biol Chem. 2003 Oct 3;278(40):39185-8. Epub 2003 Aug 7. PMID:12907689<ref>PMID:12907689</ref>
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1OJG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OJG OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The NMR structure of the sensory domain of the membranous two-component fumarate sensor (histidine protein kinase) DcuS of Escherichia coli., Pappalardo L, Janausch IG, Vijayan V, Zientz E, Junker J, Peti W, Zweckstetter M, Unden G, Griesinger C, J Biol Chem. 2003 Oct 3;278(40):39185-8. Epub 2003 Aug 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12907689 12907689]
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</div>
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[[Category: Escherichia coli]]
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<div class="pdbe-citations 1ojg" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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== References ==
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[[Category: Griesinger, C.]]
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<references/>
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[[Category: Janausch, I G.]]
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__TOC__
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[[Category: Junker, J.]]
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</StructureSection>
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[[Category: Pappalardo, L.]]
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[[Category: Large Structures]]
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[[Category: Peti, W.]]
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[[Category: Griesinger C]]
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[[Category: Unden, G.]]
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[[Category: Janausch IG]]
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[[Category: Vijayan, V.]]
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[[Category: Junker J]]
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[[Category: Zientz, E.]]
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[[Category: Pappalardo L]]
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[[Category: Zweckstetter, M.]]
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[[Category: Peti W]]
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[[Category: Dcus]]
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[[Category: Unden G]]
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[[Category: Fumarate]]
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[[Category: Vijayan V]]
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[[Category: Histidine kinase]]
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[[Category: Zientz E]]
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[[Category: Transferase]]
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[[Category: Zweckstetter M]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:55:27 2008''
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Current revision

Sensory domain of the membraneous two-component fumarate sensor DcuS of E. coli

PDB ID 1ojg

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