8ws1
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human NEK7 D161N mutant== | |
| - | + | <StructureSection load='8ws1' size='340' side='right'caption='[[8ws1]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8ws1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WS1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WS1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ws1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ws1 OCA], [https://pdbe.org/8ws1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ws1 RCSB], [https://www.ebi.ac.uk/pdbsum/8ws1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ws1 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/NEK7_HUMAN NEK7_HUMAN] Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1.<ref>PMID:17101132</ref> <ref>PMID:17586473</ref> <ref>PMID:19414596</ref> |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bearss D]] | ||
| + | [[Category: Bijpuria S]] | ||
| + | [[Category: Kanavalli M]] | ||
| + | [[Category: Mollard A]] | ||
| + | [[Category: Subbiah R]] | ||
Current revision
Crystal structure of human NEK7 D161N mutant
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