6m58

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Current revision (11:11, 30 October 2024) (edit) (undo)
 
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<StructureSection load='6m58' size='340' side='right'caption='[[6m58]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
<StructureSection load='6m58' size='340' side='right'caption='[[6m58]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6m58]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M58 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6M58 FirstGlance]. <br>
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M58 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6M58 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6m58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m58 OCA], [https://pdbe.org/6m58 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6m58 RCSB], [https://www.ebi.ac.uk/pdbsum/6m58 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6m58 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6m58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m58 OCA], [https://pdbe.org/6m58 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6m58 RCSB], [https://www.ebi.ac.uk/pdbsum/6m58 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6m58 ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
 
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== Function ==
 
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[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
 
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Cho SY]]
[[Category: Cho SY]]
[[Category: Yoon SI]]
[[Category: Yoon SI]]

Current revision

Crystal structure of a complex between human serum albumin and the antibody Fab SL335

PDB ID 6m58

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OCA

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