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| - | [[Image:1ps4.gif|left|200px]]<br /> | + | #REDIRECT [[1q2u]] This PDB entry is obsolete and replaced by 1q2u |
| - | <applet load="1ps4" size="450" color="white" frame="true" align="right" spinBox="true"
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| - | caption="1ps4, resolution 1.6Å" />
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| - | '''crystal structure of DJ-1'''<br />
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| - | ==Overview==
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| - | DJ-1 is a protein involved in multiple physiological processes, including, cancer, Parkinson's disease, and male fertility. It is unknown how DJ-1, functions in the apparently different systems. The crystal structure of, DJ-1 at 1.6 A resolution shows that DJ-1 is a helix-strand-helix sandwich, and forms a dimer. The DJ-1 structure is similar to the members of the, intracellular protease PfpI family. However, the catalytic triad of, Cys-His-Glu is not strictly conserved in DJ-1, implying that DJ-1 has a, different catalytic mechanism if it acts as a protease or DJ-1 serves as a, regulatory protein in the physiological processes. The structure shows, that Leu166 positions in the middle of a helix and thus predicts that the, L166P mutation will bend the helix and impact the dimerization of DJ-1. As, a result, the conformational changes may diminish the DJ-1 binding with, its partner, leading to the familial Parkinson's disease caused by the, single L166P mutation.
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| - | ==Disease==
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| - | Known diseases associated with this structure: Amyotrophic lateral sclerosis-Parkinsonism/dementia complex 2 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602533 602533]], Parkinson disease 7, autosomal recessive early-onset OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602533 602533]]
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| - | ==About this Structure==
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| - | 1PS4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1PS4 OCA].
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| - | ==Reference==
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| - | Crystal structure of DJ-1/RS and implication on familial Parkinson's disease., Huai Q, Sun Y, Wang H, Chin LS, Li L, Robinson H, Ke H, FEBS Lett. 2003 Aug 14;549(1-3):171-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12914946 12914946]
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| - | [[Category: Homo sapiens]]
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| - | [[Category: Single protein]]
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| - | [[Category: Chin, L.S.]]
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| - | [[Category: Huai, Q.]]
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| - | [[Category: Ke, H.]]
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| - | [[Category: Li, L.]]
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| - | [[Category: Robinson, H.]]
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| - | [[Category: Sun, Y.]]
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| - | [[Category: Wang, H.]]
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| - | [[Category: male fertility]]
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| - | [[Category: parkinson's disease]]
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| - | [[Category: regulatory protein]]
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| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 18:46:40 2007''
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