8j9n

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'''Unreleased structure'''
 
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The entry 8j9n is ON HOLD
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==Gq bound FZD1 in ligand-free state==
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<StructureSection load='8j9n' size='340' side='right'caption='[[8j9n]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8j9n]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J9N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J9N FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j9n OCA], [https://pdbe.org/8j9n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j9n RCSB], [https://www.ebi.ac.uk/pdbsum/8j9n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j9n ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The ten Frizzled receptors (FZDs) are essential in Wnt signaling and play important roles in embryonic development and tumorigenesis. Among these, FZD6 is closely associated with lens development. Understanding FZD activation mechanism is key to unlock these emerging targets. Here we present the cryo-EM structures of FZD6 and FZD3 which are known to relay non-canonical planar cell polarity (PCP) signaling pathways as well as FZD1 in their G protein-coupled states and in the apo inactive states, respectively. Comparison of the three inactive/active pairs unveiled a shared activation framework among all ten FZDs. Mutagenesis along with imaging and functional analysis on the human lens epithelial tissues suggested potential crosstalk between the G-protein coupling of FZD6 and the PCP signaling pathways. Together, this study provides an integrated understanding of FZD structure and function, and lays the foundation for developing therapeutic modulators to activate or inhibit FZD signaling for a range of disorders including cancers and cataracts.
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Authors: Lin, X., Xu, F.
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A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways.,Zhang Z, Lin X, Wei L, Wu Y, Xu L, Wu L, Wei X, Zhao S, Zhu X, Xu F Cell Discov. 2024 Jan 5;10(1):3. doi: 10.1038/s41421-023-00627-y. PMID:38182578<ref>PMID:38182578</ref>
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Description: Gq bound FZD1 in ligand-free state
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Xu, F]]
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<div class="pdbe-citations 8j9n" style="background-color:#fffaf0;"></div>
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[[Category: Lin, X]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Vicugna pacos]]
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[[Category: Lin X]]
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[[Category: Xu F]]

Current revision

Gq bound FZD1 in ligand-free state

PDB ID 8j9n

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