8v4s
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of the rat P2X7 receptor in the apo closed state purified in the absence of sodium== | |
| - | + | <StructureSection load='8v4s' size='340' side='right'caption='[[8v4s]], [[Resolution|resolution]] 2.49Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8v4s]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus Rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8V4S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8V4S FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.49Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8v4s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8v4s OCA], [https://pdbe.org/8v4s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8v4s RCSB], [https://www.ebi.ac.uk/pdbsum/8v4s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8v4s ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/P2RX7_RAT P2RX7_RAT] Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rattus]] | ||
| + | [[Category: Glasfeld A]] | ||
| + | [[Category: Godsey MH]] | ||
| + | [[Category: Krishnamurthy I]] | ||
| + | [[Category: Lisi NE]] | ||
| + | [[Category: Mansoor SE]] | ||
| + | [[Category: McCarthy AE]] | ||
| + | [[Category: Oken AC]] | ||
Current revision
Cryo-EM structure of the rat P2X7 receptor in the apo closed state purified in the absence of sodium
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Categories: Large Structures | Rattus | Glasfeld A | Godsey MH | Krishnamurthy I | Lisi NE | Mansoor SE | McCarthy AE | Oken AC
