8x8s
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Cypovirus Polyhedra mutant fused with c-Myc fragment== | |
| - | + | <StructureSection load='8x8s' size='340' side='right'caption='[[8x8s]], [[Resolution|resolution]] 2.04Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8x8s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombyx_mori_cypovirus_1 Bombyx mori cypovirus 1] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8X8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8X8S FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8x8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8x8s OCA], [https://pdbe.org/8x8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8x8s RCSB], [https://www.ebi.ac.uk/pdbsum/8x8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8x8s ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Abe | + | == Disease == |
| - | [[Category: Hirata | + | [https://www.uniprot.org/uniprot/MYC_HUMAN MYC_HUMAN] Note=Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. Note=A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1. Defects in MYC are a cause of Burkitt lymphoma (BL) [MIM:[https://omim.org/entry/113970 113970]. A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. Note=Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci. |
| - | [[Category: Ueno | + | == Function == |
| + | [https://www.uniprot.org/uniprot/PYHD_CPVBM PYHD_CPVBM] Major component of the virus occlusion bodies, which are large proteinaceous structures (polyhedra), that protect the virus from the outside environment for extended periods until they are ingested by insect larvae.[https://www.uniprot.org/uniprot/MYC_HUMAN MYC_HUMAN] Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bombyx mori cypovirus 1]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Abe S]] | ||
| + | [[Category: Hirata K]] | ||
| + | [[Category: Kojima M]] | ||
| + | [[Category: Ueno T]] | ||
Current revision
Crystal structure of Cypovirus Polyhedra mutant fused with c-Myc fragment
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