Syntrophin
From Proteopedia
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<StructureSection load='1qav' size='350' side='right' caption='Mouse syntrophin PDZ domain (deepskyblue) complex with neuronal NOS (green) (PDB code [[1qav]])' scene='77/777075/Cv/1'> | <StructureSection load='1qav' size='350' side='right' caption='Mouse syntrophin PDZ domain (deepskyblue) complex with neuronal NOS (green) (PDB code [[1qav]])' scene='77/777075/Cv/1'> | ||
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== Function == | == Function == | ||
'''Syntrophins''' (Syn) are a family of membrane-associated adaptor proteins which are important components of many signaling events: regulating the postsynaptic signal transduction, sarcolemmal localization of brain NOS and G-protein mediated signaling <ref>PMID:23263165</ref>. | '''Syntrophins''' (Syn) are a family of membrane-associated adaptor proteins which are important components of many signaling events: regulating the postsynaptic signal transduction, sarcolemmal localization of brain NOS and G-protein mediated signaling <ref>PMID:23263165</ref>. | ||
| + | *'''alpha-1-syntrophin''' is a cytoskeletal protein interacting with cardiac sodium channel<ref>PMID:19684871</ref>. | ||
| + | *'''beta-1-syntrophin''' is a scaffold protein that provides a platform for the formation of signal transduction complexes<ref>PMID:34277816</ref>. | ||
== Disease == | == Disease == | ||
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Syn is characterized by a plekstrin homology domain(PH) which is split by a PDZ domain and a C-terminal Syn unique domain. <scene name='77/777075/Cv/3'>Syn binds the neuronal NOS</scene> β-finger via its binding groove<ref>PMID:10221915</ref>. | Syn is characterized by a plekstrin homology domain(PH) which is split by a PDZ domain and a C-terminal Syn unique domain. <scene name='77/777075/Cv/3'>Syn binds the neuronal NOS</scene> β-finger via its binding groove<ref>PMID:10221915</ref>. | ||
| - | </StructureSection> | ||
== 3D Structures of syntrophin == | == 3D Structures of syntrophin == | ||
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== References == | == References == | ||
<references/> | <references/> | ||
| - | + | </StructureSection> | |
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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