8v7o
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8v7o is ON HOLD Authors: Nagashima, K.A., Mousa, J.J. Description: Fab fragment of human mAb #58 in complex with computationally optimized broadly ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Fab fragment of human mAb #58 in complex with computationally optimized broadly reactive H1 influenza hemagglutinin X6== | |
| + | <StructureSection load='8v7o' size='340' side='right'caption='[[8v7o]], [[Resolution|resolution]] 3.57Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8v7o]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8V7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8V7O FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.57Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8v7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8v7o OCA], [https://pdbe.org/8v7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8v7o RCSB], [https://www.ebi.ac.uk/pdbsum/8v7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8v7o ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Influenza causes significant morbidity and mortality. As an alternative approach to current seasonal vaccines, the computationally optimized broadly reactive antigen (COBRA) platform has been previously applied to hemagglutinin (HA). This approach integrates wild-type HA sequences into a single immunogen to expand the breadth of accessible antibody epitopes. Adding to previous studies of H1, H3, and H5 COBRA HAs, we define the structural features of another H1 subtype COBRA, X6, that incorporates HA sequences from before and after the 2009 H1N1 influenza pandemic. We determined structures of this antigen alone and in complex with COBRA-specific as well as broadly reactive and functional antibodies, analyzing its antigenicity. We found that X6 possesses features representing both historic and recent H1 HA strains, enabling binding to both head- and stem-reactive antibodies. Overall, these data confirm the integrity of broadly reactive antibody epitopes of X6 and contribute to design efforts for a next-generation vaccine. | ||
| - | + | Structural basis for the broad antigenicity of the computationally optimized influenza hemagglutinin X6.,Nagashima KA, Dzimianski JV, Yang M, Abendroth J, Sautto GA, Ross TM, DuBois RM, Edwards TE, Mousa JJ Structure. 2024 May 24:S0969-2126(24)00178-3. doi: 10.1016/j.str.2024.05.001. PMID:38810648<ref>PMID:38810648</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Mousa | + | <div class="pdbe-citations 8v7o" style="background-color:#fffaf0;"></div> |
| - | [[Category: Nagashima | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Influenza A virus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mousa JJ]] | ||
| + | [[Category: Nagashima KA]] | ||
Current revision
Fab fragment of human mAb #58 in complex with computationally optimized broadly reactive H1 influenza hemagglutinin X6
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