8v8i
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==PI3Ka H1047R co-crystal structure with inhibitor in cryptic pocket (compound 5).== | |
| - | + | <StructureSection load='8v8i' size='340' side='right'caption='[[8v8i]], [[Resolution|resolution]] 3.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8v8i]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8V8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8V8I FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=YNZ:(2S)-N~1~-[(4P)-2-tert-butyl-4-methyl[4,5-bi-1,3-thiazol]-2-yl]pyrrolidine-1,2-dicarboxamide'>YNZ</scene>, <scene name='pdbligand=YOR:N-{(3S)-3-(2-methylphenyl)-6-[(oxetan-3-yl)amino]-1-oxo-2,3-dihydro-1H-isoindol-4-yl}-1-benzothiophene-3-carboxamide'>YOR</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8v8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8v8i OCA], [https://pdbe.org/8v8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8v8i RCSB], [https://www.ebi.ac.uk/pdbsum/8v8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8v8i ProSAT]</span></td></tr> |
| - | [[Category: Gunn | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/P85A_HUMAN P85A_HUMAN] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.<ref>PMID:7518429</ref> <ref>PMID:17626883</ref> <ref>PMID:19805105</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Gunn RJ]] | ||
| + | [[Category: Lawson JD]] | ||
Current revision
PI3Ka H1047R co-crystal structure with inhibitor in cryptic pocket (compound 5).
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