8v92
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==BRD4 BD1 liganded with macrocyclic compound 2b (JJ-II-352A)== | |
| - | + | <StructureSection load='8v92' size='340' side='right'caption='[[8v92]], [[Resolution|resolution]] 1.27Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8v92]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8V92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8V92 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.27Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1AAL:(4bS)-1-ethyl-21-methyl-4b,11,12,22-tetrahydro-2H,10H,18H-dibenzo[13,14 6,7][1,5,9]trioxacyclotetradecino[12,11 4,5]pyrido[2,3-d]pyrimidine-2,4,20(1H,3H)-trione'>A1AAL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8v92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8v92 OCA], [https://pdbe.org/8v92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8v92 RCSB], [https://www.ebi.ac.uk/pdbsum/8v92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8v92 ProSAT]</span></td></tr> |
| - | [[Category: Chan | + | </table> |
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chan A]] | ||
| + | [[Category: Schonbrunn E]] | ||
Current revision
BRD4 BD1 liganded with macrocyclic compound 2b (JJ-II-352A)
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