8bu0
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bu0 OCA], [https://pdbe.org/8bu0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bu0 RCSB], [https://www.ebi.ac.uk/pdbsum/8bu0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bu0 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bu0 OCA], [https://pdbe.org/8bu0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bu0 RCSB], [https://www.ebi.ac.uk/pdbsum/8bu0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bu0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | As protein crystals are increasingly finding diverse applications as scaffolds, controlled crystal polymorphism presents a facile strategy to form crystalline assemblies with controllable porosity with minimal to no protein engineering. Polymorphs of consensus tetratricopeptide repeat proteins with varying porosity were obtained through co-crystallization with metal salts, exploiting the innate metal ion geometric requirements. A single structurally exposed negative amino acid cluster was responsible for metal coordination, despite the abundance of negatively charged residues. Density functional theory calculations showed that while most of the crystals were the most thermodynamically stable assemblies, some were kinetically trapped states. Thus, crystalline porosity diversity is achieved and controlled with metal coordination, opening a new scope in the application of proteins as biocompatible protein-metal-organic frameworks (POFs). In addition, metal-dependent polymorphic crystals allow direct comparison of metal coordination preferences. | ||
| + | |||
| + | Diverse crystalline protein scaffolds through metal-dependent polymorphism.,Liutkus M, Sasselli IR, Rojas AL, Cortajarena AL Protein Sci. 2024 May;33(5):e4971. doi: 10.1002/pro.4971. PMID:38591647<ref>PMID:38591647</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 8bu0" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Crystal structure of an 8 repeat consensus TPR superhelix with calcium
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