8rh0
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8rh0 is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Trimeric HSV-1F gB ectodomain in postfusion conformation with three bound HDIT102 Fab molecules.== | |
| - | + | <StructureSection load='8rh0' size='340' side='right'caption='[[8rh0]], [[Resolution|resolution]] 3.44Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8rh0]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1 Human alphaherpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RH0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.44Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rh0 OCA], [https://pdbe.org/8rh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rh0 RCSB], [https://www.ebi.ac.uk/pdbsum/8rh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rh0 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GB_HHV1F GB_HHV1F] Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moities of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding of gD to one of its receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation) (By similarity).<ref>PMID:17548810</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Human alphaherpesvirus 1]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arndt M]] | ||
| + | [[Category: Blumenschein E]] | ||
| + | [[Category: Chami M]] | ||
| + | [[Category: Diebolder P]] | ||
| + | [[Category: Eckert D]] | ||
| + | [[Category: Engel R]] | ||
| + | [[Category: Imhof T]] | ||
| + | [[Category: Jenner L]] | ||
| + | [[Category: Kalbermatter D]] | ||
| + | [[Category: Krauss J]] | ||
| + | [[Category: Moog K]] | ||
| + | [[Category: Mueller C]] | ||
| + | [[Category: Ries M]] | ||
| + | [[Category: Schaller T]] | ||
| + | [[Category: Seyfizadeh N]] | ||
| + | [[Category: Yendrzheyevskiy A]] | ||
Current revision
Trimeric HSV-1F gB ectodomain in postfusion conformation with three bound HDIT102 Fab molecules.
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Categories: Homo sapiens | Human alphaherpesvirus 1 | Large Structures | Arndt M | Blumenschein E | Chami M | Diebolder P | Eckert D | Engel R | Imhof T | Jenner L | Kalbermatter D | Krauss J | Moog K | Mueller C | Ries M | Schaller T | Seyfizadeh N | Yendrzheyevskiy A
