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1okx
From Proteopedia
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(New page: 200px<br /> <applet load="1okx" size="450" color="white" frame="true" align="right" spinBox="true" caption="1okx, resolution 2.80Å" /> '''BINDING STRUCTURE O...) |
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| - | [[Image:1okx.gif|left|200px]]<br /> | ||
| - | <applet load="1okx" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1okx, resolution 2.80Å" /> | ||
| - | '''BINDING STRUCTURE OF ELASTASE INHIBITOR SCYPTOLIN A'''<br /> | ||
| - | == | + | ==Binding Structure of Elastase Inhibitor Scyptolin A== |
| - | Natural bioactive compounds are of general interest to pharmaceutical | + | <StructureSection load='1okx' size='340' side='right'caption='[[1okx]], [[Resolution|resolution]] 2.80Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1okx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Scytonema_hofmannii Scytonema hofmannii] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OKX FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1BO:1-BUTANOL'>1BO</scene>, <scene name='pdbligand=CNT:N-METHYL-META-CHLORO-TYROSINE'>CNT</scene>, <scene name='pdbligand=SUJ:(2R,3R)-2-[(3S,6R)-3-AMINO-6-HYDROXY-2-OXOPIPERIDINYL]-3-HYDROXYBUTANOIC+ACID'>SUJ</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1okx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1okx OCA], [https://pdbe.org/1okx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1okx RCSB], [https://www.ebi.ac.uk/pdbsum/1okx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1okx ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CELA1_PIG CELA1_PIG] Acts upon elastin. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ok/1okx_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1okx ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Natural bioactive compounds are of general interest to pharmaceutical research because they may be used as leads in drug development campaigns. Among them, scyptolin A and B from Scytonema hofmanni PCC 7110 are known to inhibit porcine pancreatic elastase, which in turn resembles the attractive drug target neutrophil elastase. The crystal structure of scyptolin A as bound to pancreatic elastase was solved at 2.8 A resolution. The inhibitor occupies the most prominent subsites S1 through S4 of the elastase and prevents a hydrolytic attack by covering the active center with its rigid ring structure. The observed binding structure may help to design potent elastase inhibitors. | ||
| - | + | Binding structure of elastase inhibitor scyptolin A.,Matern U, Schleberger C, Jelakovic S, Weckesser J, Schulz GE Chem Biol. 2003 Oct;10(10):997-1001. PMID:14583266<ref>PMID:14583266</ref> | |
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| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 1okx" style="background-color:#fffaf0;"></div> | |
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| - | + | ==See Also== | |
| + | *[[Elastase 3D structures|Elastase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Scytonema hofmannii]] | ||
| + | [[Category: Sus scrofa]] | ||
| + | [[Category: Jelakovic S]] | ||
| + | [[Category: Matern U]] | ||
| + | [[Category: Schleberger C]] | ||
| + | [[Category: Schulz GE]] | ||
| + | [[Category: Weckesser J]] | ||
Current revision
Binding Structure of Elastase Inhibitor Scyptolin A
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