8xcj
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Open State of central tail fiber of bacteriophage lambda upon binding to LamB (gpJ713-LamB complex)== | |
| + | <StructureSection load='8xcj' size='340' side='right'caption='[[8xcj]], [[Resolution|resolution]] 2.98Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8xcj]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_Lambda Escherichia phage Lambda] and [https://en.wikipedia.org/wiki/Shigella_sonnei Shigella sonnei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XCJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XCJ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.98Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xcj OCA], [https://pdbe.org/8xcj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xcj RCSB], [https://www.ebi.ac.uk/pdbsum/8xcj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xcj ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A0I1R9L6_SHISO A0A0I1R9L6_SHISO] Involved in the transport of maltose and maltodextrins.[HAMAP-Rule:MF_01301] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Bacteriophage infection, a pivotal process in microbiology, initiates with the phage's tail recognizing and binding to the bacterial cell surface, which then mediates the injection of viral DNA. Although comprehensive studies on the interaction between bacteriophage lambda and its outer membrane receptor, LamB, have provided rich information about the system's biochemical properties, the precise molecular mechanism remains undetermined. This study revealed the high-resolution cryo-electron microscopy (cryo-EM) structures of the bacteriophage lambda tail complexed with its irreversible Shigella sonnei 3070 LamB receptor and the closed central tail fiber. These structures reveal the complex processes that trigger infection and demonstrate a substantial conformational change in the phage lambda tail tip upon LamB binding. Providing detailed structures of bacteriophage lambda infection initiation, this study contributes to the expanding knowledge of lambda-bacterial interaction, which holds significance in the fields of microbiology and therapeutic development. | ||
| - | + | Structural mechanism of bacteriophage lambda tail's interaction with the bacterial receptor.,Ge X, Wang J Nat Commun. 2024 May 17;15(1):4185. doi: 10.1038/s41467-024-48686-3. PMID:38760367<ref>PMID:38760367</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 8xcj" style="background-color:#fffaf0;"></div> |
| - | [[Category: Ge | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia phage Lambda]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Shigella sonnei]] | ||
| + | [[Category: Ge XF]] | ||
| + | [[Category: Wang JW]] | ||
Current revision
Open State of central tail fiber of bacteriophage lambda upon binding to LamB (gpJ713-LamB complex)
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