1pbv

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[[Image:1pbv.gif|left|200px]]
 
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==SEC7 DOMAIN OF THE EXCHANGE FACTOR ARNO==
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The line below this paragraph, containing "STRUCTURE_1pbv", creates the "Structure Box" on the page.
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<StructureSection load='1pbv' size='340' side='right'caption='[[1pbv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pbv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PBV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PBV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pbv OCA], [https://pdbe.org/1pbv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pbv RCSB], [https://www.ebi.ac.uk/pdbsum/1pbv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pbv ProSAT]</span></td></tr>
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{{STRUCTURE_1pbv| PDB=1pbv | SCENE= }}
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</table>
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== Function ==
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'''SEC7 DOMAIN OF THE EXCHANGE FACTOR ARNO'''
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[https://www.uniprot.org/uniprot/CYH2_HUMAN CYH2_HUMAN] Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane.<ref>PMID:17398095</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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Small G proteins switch from a resting, GDP-bound state to an active, GTP-bound state. As spontaneous GDP release is slow, guanine-nucleotide-exchange factors (GEFs) are required to promote fast activation of small G proteins through replacement of GDP with GTP in vivo. Families of GEFs with no sequence similarity to other GEF families have now been assigned to most families of small G proteins. In the case of the small G protein Arf1, the exchange of bound GDP for GTP promotes the coating of secretory vesicles in Golgi traffic. An exchange factor for human Arf1, ARNO, and two closely related proteins, named cytohesin 1 and GPS1, have been identified. These three proteins are modular proteins with an amino-terminal coiled-coil, a central Sec7-like domain and a carboxy-terminal pleckstrin homology domain. The Sec7 domain contains the exchange-factor activity. It was first found in Sec7, a yeast protein involved in secretion, and is present in several other proteins, including the yeast exchange factors for Arf, Geal and Gea2. Here we report the crystal structure of the Sec7 domain of human ARNO at 2 A resolution and the identification of the site of interaction of ARNO with Arf.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pb/1pbv_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1PBV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PBV OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pbv ConSurf].
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Structure of the Sec7 domain of the Arf exchange factor ARNO., Cherfils J, Menetrey J, Mathieu M, Le Bras G, Robineau S, Beraud-Dufour S, Antonny B, Chardin P, Nature. 1998 Mar 5;392(6671):101-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9510256 9510256]
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Antonny, B.]]
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[[Category: Antonny B]]
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[[Category: Beraud-Dufour, S.]]
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[[Category: Beraud-Dufour S]]
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[[Category: Bras, G Le.]]
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[[Category: Chardin P]]
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[[Category: Chardin, P.]]
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[[Category: Cherfils J]]
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[[Category: Cherfils, J.]]
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[[Category: Le Bras G]]
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[[Category: Mathieu, M.]]
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[[Category: Mathieu M]]
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[[Category: Menetrey, J.]]
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[[Category: Menetrey J]]
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[[Category: Robineau, S.]]
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[[Category: Robineau S]]
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[[Category: Arf functional class: guanine nucleotide exchange factor]]
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[[Category: Arno]]
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[[Category: Exchange factor]]
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[[Category: Sec7]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:55:05 2008''
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Current revision

SEC7 DOMAIN OF THE EXCHANGE FACTOR ARNO

PDB ID 1pbv

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