1pjb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:08, 14 February 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1pjb.jpg|left|200px]]
 
-
<!--
+
==L-ALANINE DEHYDROGENASE==
-
The line below this paragraph, containing "STRUCTURE_1pjb", creates the "Structure Box" on the page.
+
<StructureSection load='1pjb' size='340' side='right'caption='[[1pjb]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1pjb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phormidium_lapideum Phormidium lapideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PJB FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pjb OCA], [https://pdbe.org/1pjb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pjb RCSB], [https://www.ebi.ac.uk/pdbsum/1pjb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pjb ProSAT]</span></td></tr>
-
{{STRUCTURE_1pjb| PDB=1pjb | SCENE= }}
+
</table>
-
 
+
== Function ==
-
'''L-ALANINE DEHYDROGENASE'''
+
[https://www.uniprot.org/uniprot/O52942_PHOLP O52942_PHOLP]
-
 
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
==Overview==
+
Check<jmol>
-
The structure of the hexameric L-alanine dehydrogenase from Phormidium lapideum reveals that the subunit is constructed from two domains, each having the common dinucleotide binding fold. Despite there being no sequence similarity, the fold of alanine dehydrogenase is closely related to that of the family of D-2-hydroxyacid dehydrogenases, with a similar location of the active site, suggesting that these enzymes are related by divergent evolution. L-alanine dehydrogenase and the 2-hydroxyacid dehydrogenases also use equivalent functional groups to promote substrate recognition and catalysis. However, they are arranged differently on the enzyme surface, which has the effect of directing opposite faces of the keto acid to the dinucleotide in each case, forcing a change in absolute configuration of the product.
+
<jmolCheckbox>
-
 
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pj/1pjb_consurf.spt"</scriptWhenChecked>
-
==About this Structure==
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
1PJB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Phormidium_lapideum Phormidium lapideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJB OCA].
+
<text>to colour the structure by Evolutionary Conservation</text>
-
 
+
</jmolCheckbox>
-
==Reference==
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pjb ConSurf].
-
Analysis of the structure and substrate binding of Phormidium lapideum alanine dehydrogenase., Baker PJ, Sawa Y, Shibata H, Sedelnikova SE, Rice DW, Nat Struct Biol. 1998 Jul;5(7):561-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9665169 9665169]
+
<div style="clear:both"></div>
-
[[Category: Alanine dehydrogenase]]
+
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Phormidium lapideum]]
[[Category: Phormidium lapideum]]
-
[[Category: Single protein]]
+
[[Category: Baker PJ]]
-
[[Category: Baker, P J.]]
+
[[Category: Rice DW]]
-
[[Category: Rice, D W.]]
+
[[Category: Sawa Y]]
-
[[Category: Sawa, Y.]]
+
[[Category: Sedelnikova SE]]
-
[[Category: Sedelnikova, S E.]]
+
[[Category: Shibata H]]
-
[[Category: Shibata, H.]]
+
-
[[Category: Nad]]
+
-
[[Category: Oxidoreductase]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:08:55 2008''
+

Current revision

L-ALANINE DEHYDROGENASE

PDB ID 1pjb

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pjb"
Personal tools