8v3m
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==CCP5 apo structure== | |
| - | + | <StructureSection load='8v3m' size='340' side='right'caption='[[8v3m]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8v3m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8V3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8V3M FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MLT:D-MALATE'>MLT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8v3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8v3m OCA], [https://pdbe.org/8v3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8v3m RCSB], [https://www.ebi.ac.uk/pdbsum/8v3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8v3m ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/CBPC5_HUMAN CBPC5_HUMAN] Retinitis pigmentosa. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CBPC5_HUMAN CBPC5_HUMAN] Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin. Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation.[UniProtKB:Q09M02] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chen J]] | ||
| + | [[Category: Gruschus JM]] | ||
| + | [[Category: Liu Y]] | ||
| + | [[Category: Roll-Mecak A]] | ||
| + | [[Category: Szyk A]] | ||
| + | [[Category: Tanner ME]] | ||
| + | [[Category: Tjandra N]] | ||
| + | [[Category: Zehr EA]] | ||
Current revision
CCP5 apo structure
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Categories: Homo sapiens | Large Structures | Chen J | Gruschus JM | Liu Y | Roll-Mecak A | Szyk A | Tanner ME | Tjandra N | Zehr EA
