8xs8
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8xs8 is ON HOLD Authors: Diao, X., Shang, Q., Wu, D. Description: Crystal structure of the DNA-bound AHR-ARNT heterodimer in complex with Benzo[a]p...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the DNA-bound AHR-ARNT heterodimer in complex with Benzo[a]pyrene== | |
| - | + | <StructureSection load='8xs8' size='340' side='right'caption='[[8xs8]], [[Resolution|resolution]] 3.11Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8xs8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XS8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.11Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=W62:benzo[a]pyrene'>W62</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xs8 OCA], [https://pdbe.org/8xs8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xs8 RCSB], [https://www.ebi.ac.uk/pdbsum/8xs8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xs8 ProSAT]</span></td></tr> |
| - | [[Category: Diao | + | </table> |
| - | [[Category: Wu | + | == Function == |
| + | [https://www.uniprot.org/uniprot/ARNT_HUMAN ARNT_HUMAN] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Sus scrofa]] | ||
| + | [[Category: Diao X]] | ||
| + | [[Category: Shang Q]] | ||
| + | [[Category: Wu D]] | ||
Current revision
Crystal structure of the DNA-bound AHR-ARNT heterodimer in complex with Benzo[a]pyrene
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Categories: Homo sapiens | Large Structures | Sus scrofa | Diao X | Shang Q | Wu D
