1pkq

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[[Image:1pkq.gif|left|200px]]
 
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==Myelin Oligodendrocyte Glycoprotein-(8-18C5) Fab-complex==
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The line below this paragraph, containing "STRUCTURE_1pkq", creates the "Structure Box" on the page.
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<StructureSection load='1pkq' size='340' side='right'caption='[[1pkq]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pkq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PKQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pkq OCA], [https://pdbe.org/1pkq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pkq RCSB], [https://www.ebi.ac.uk/pdbsum/1pkq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pkq ProSAT]</span></td></tr>
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{{STRUCTURE_1pkq| PDB=1pkq | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MOG_RAT MOG_RAT] Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pk/1pkq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pkq ConSurf].
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<div style="clear:both"></div>
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'''Myelin Oligodendrocyte Glycoprotein-(8-18C5) Fab-complex'''
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==See Also==
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[3D structures of non-human antibody|3D structures of non-human antibody]]
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==Overview==
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__TOC__
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Multiple sclerosis is a chronic disease of the central nervous system (CNS) characterized by inflammation, demyelination, and axonal loss. The immunopathogenesis of demyelination in multiple sclerosis involves an autoantibody response to myelin oligodendrocyte glycoprotein (MOG), a type I transmembrane protein located at the surface of CNS myelin. Here we present the crystal structures of the extracellular domain of MOG (MOGIgd) at 1.45-A resolution and the complex of MOGIgd with the antigen-binding fragment (Fab) of the MOG-specific demyelinating monoclonal antibody 8-18C5 at 3.0-A resolution. MOGIgd adopts an IgV like fold with the A'GFCC'C" sheet harboring a cavity similar to the one used by the costimulatory molecule B7-2 to bind its ligand CTLA4. The antibody 8-18C5 binds to three loops located at the membrane-distal side of MOG with a surprisingly dominant contribution made by MOG residues 101-108 containing a strained loop that forms the upper edge of the putative ligand binding site. The sequence R101DHSYQEE108 is unique for MOG, whereas large parts of the remaining sequence are conserved in potentially tolerogenic MOG homologues expressed outside the immuno-privileged environment of the CNS. Strikingly, the only sequence identical to DHSYQEE was found in a Chlamydia trachomatis protein of unknown function, raising the possibility that Chlamydia infections may play a role in the MOG-specific autoimmune response in man. Our data provide the structural basis for the development of diagnostic and therapeutic strategies targeting the pathogenic autoantibody response to MOG.
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</StructureSection>
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[[Category: Large Structures]]
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==About this Structure==
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1PKQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKQ OCA].
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==Reference==
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Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein., Breithaupt C, Schubart A, Zander H, Skerra A, Huber R, Linington C, Jacob U, Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9446-51. Epub 2003 Jul 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12874380 12874380]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Breithaupt C]]
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[[Category: Breithaupt, C.]]
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[[Category: Huber R]]
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[[Category: Huber, R.]]
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[[Category: Jacob U]]
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[[Category: Jacob, U.]]
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[[Category: Linington C]]
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[[Category: Linington, C.]]
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[[Category: Schubart A]]
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[[Category: Schubart, A.]]
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[[Category: Skerra A]]
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[[Category: Skerra, A.]]
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[[Category: Zander H]]
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[[Category: Zander, H.]]
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[[Category: Autoantibody]]
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[[Category: Eae]]
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[[Category: Multiple sclerosis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:11:45 2008''
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Current revision

Myelin Oligodendrocyte Glycoprotein-(8-18C5) Fab-complex

PDB ID 1pkq

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