Bupivacaine
From Proteopedia
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(New page: <StructureSection load='' size='340' side='right' caption='Caption for this structure' scene=''> Bupivacaine, marketed under the brand name Marcaine among others, is a medication used to d...) |
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| - | <StructureSection load='' size='340' side='right' caption='Caption for this structure' scene=''> | + | <StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='10/1023607/Cv/2'> |
| - | Bupivacaine, marketed under the brand name Marcaine among others, is a medication used to decrease feeling in a specific area. | + | Bupivacaine, marketed under the brand name Marcaine among others, is a medication used to decrease feeling in a specific area. In nerve blocks, it is injected around a nerve that supplies the area, or into the spinal canal's epidural space. It is available mixed with a small amount of epinephrine to increase the duration of its action.<ref name="a5">[https://www.drugs.com/monograph/bupivacaine-local.html "Bupivacaine Hydrochloride".] The American Society of Health-System Pharmacists. Archived from the original on 2015-06-30. Retrieved August 1, 2015.</ref> See also [https://en.wikipedia.org/wiki/Bupivacaine Bupivacaine]. |
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| + | Bupivacaine binds to the intracellular portion of voltage-gated sodium (Nav) channels and blocks sodium influx into nerve cells, which prevents depolarization. Without depolarization, no initiation or conduction of a pain signal can occur. | ||
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| + | <scene name='10/1023607/Cv/3'>Human Nav1.7 in complex with bupivacaine</scene> ([[8i5b]]). | ||
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| + | <scene name='10/1023607/Cv/4'>Bupivacaine binding site</scene>. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
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References
- ↑ "Bupivacaine Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 2015-06-30. Retrieved August 1, 2015.
