1pl7

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[[Image:1pl7.gif|left|200px]]
 
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==Human Sorbitol Dehydrogenase (apo)==
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The line below this paragraph, containing "STRUCTURE_1pl7", creates the "Structure Box" on the page.
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<StructureSection load='1pl7' size='340' side='right'caption='[[1pl7]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pl7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PL7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1pl7| PDB=1pl7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pl7 OCA], [https://pdbe.org/1pl7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pl7 RCSB], [https://www.ebi.ac.uk/pdbsum/1pl7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pl7 ProSAT]</span></td></tr>
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</table>
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'''Human Sorbitol Dehydrogenase (apo)'''
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== Function ==
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[https://www.uniprot.org/uniprot/DHSO_HUMAN DHSO_HUMAN] Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm (By similarity).<ref>PMID:16278369</ref>
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Sorbitol dehydrogenase (hSDH) and aldose reductase form the polyol pathway that interconverts glucose and fructose. Redox changes from overproduction of the coenzyme NADH by SDH may play a role in diabetes-induced dysfunction in sensitive tissues, making SDH a therapeutic target for diabetic complications. We have purified and determined the crystal structures of human SDH alone, SDH with NAD(+), and SDH with NADH and an inhibitor that is competitive with fructose. hSDH is a tetramer of identical, catalytically active subunits. In the apo and NAD(+) complex, the catalytic zinc is coordinated by His69, Cys44, Glu70, and a water molecule. The inhibitor coordinates the zinc through an oxygen and a nitrogen atom with the concomitant dissociation of Glu70. The inhibitor forms hydrophobic interactions to NADH and likely sterically occludes substrate binding. The structure of the inhibitor complex provides a framework for developing more potent inhibitors of hSDH.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pl/1pl7_consurf.spt"</scriptWhenChecked>
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1PL7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL7 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase., Pauly TA, Ekstrom JL, Beebe DA, Chrunyk B, Cunningham D, Griffor M, Kamath A, Lee SE, Madura R, Mcguire D, Subashi T, Wasilko D, Watts P, Mylari BL, Oates PJ, Adams PD, Rath VL, Structure. 2003 Sep;11(9):1071-85. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12962626 12962626]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pl7 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: L-iditol 2-dehydrogenase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Adams PD]]
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[[Category: Adams, P D.]]
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[[Category: Beebe DA]]
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[[Category: Beebe, D A.]]
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[[Category: Chrunyk B]]
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[[Category: Chrunyk, B.]]
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[[Category: Cunningham D]]
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[[Category: Cunningham, D.]]
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[[Category: Ekstrom JL]]
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[[Category: Ekstrom, J L.]]
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[[Category: Griffor M]]
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[[Category: Griffor, M.]]
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[[Category: Kamath A]]
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[[Category: Kamath, A.]]
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[[Category: Lee SE]]
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[[Category: Lee, S E.]]
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[[Category: Madura R]]
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[[Category: Madura, R.]]
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[[Category: Mcguire D]]
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[[Category: Mcguire, D.]]
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[[Category: Mylari BL]]
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[[Category: Mylari, B L.]]
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[[Category: Oates PJ]]
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[[Category: Oates, P J.]]
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[[Category: Pauly TA]]
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[[Category: Pauly, T A.]]
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[[Category: Rath VL]]
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[[Category: Rath, V L.]]
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[[Category: Subashi T]]
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[[Category: Subashi, T.]]
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[[Category: Wasilko D]]
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[[Category: Wasilko, D.]]
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[[Category: Watts P]]
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[[Category: Watts, P.]]
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[[Category: Human sorbitol dehydrogenase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:12:50 2008''
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Current revision

Human Sorbitol Dehydrogenase (apo)

PDB ID 1pl7

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